Abstract Nanomaterials and nanotechnologies (NNs) have been shaping the wastewater treatment process unprecedentedly. Bibliometric methods are regarded as an indispensable light to guide direction in scientific domain. The present study aims to investigate the role of NNs in wastewater treatment with bibliometric techniques based on SCI databases from 1997 to 2016. Results showed that China (962), USA (324) and Iran (140) are the most productive countries. Chinese Academy of Sciences (149), Tongji University (49), and Harbin Institute of Technology (40) from China are the most contributive institutions. China and USA played central roles in cross-national cooperation, but the top three Chinese institutions displayed limited vitality in overseas communication. Rsc Advances (108) was the most productive journal followed by Desalination (97) and Desalination and Water Treatment (96). The research direction of NNs in wastewater treatment was bound up with new NNs. Novel preparation methods and nanostructures were powerful impetus for its progress. Nanomaterials like graphene, nanotube, magnetic nanoparticle, and silver nanoparticle were hotpots in this field. Current and potential application of NNs in wastewater treatment as well as challenges were reviewed based on bibliometric results. This study also provided researchers future-minded advice about research topic selection.