Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer

Abstract Background Breast cancer (BC) is the most common cancer in women, and despite the introduction of new screening programmes, therapies and monitoring technologies, there is still a need to develop more useful tests for monitoring treatment response and to inform clinical decision making. The purpose of this study was to compare circulating cell-free DNA (cfDNA) and circulating tumour cells (CTCs) with conventional breast cancer blood biomarkers (CA15-3 and alkaline phosphatase (AP)) as predictors of response to treatment and prognosis in patients with metastatic breast cancer (MBC). Methods One hundred ninety-four female patients with radiologically confirmed MBC were recruited to the study. Total cfDNA levels were determined by qPCR and compared with CELLSEARCH® CTC counts and CA15-3 and alkaline phosphatase (AP) values. Blood biomarker data were compared with conventional tumour markers, treatment(s) and response as assessed by RECIST and survival. Non-parametric statistical hypothesis tests were us...

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PID https://www.doi.org/10.1186/s13058-019-1235-8
PID https://www.doi.org/10.6084/m9.figshare.c.4792053.v1
PID https://www.doi.org/10.6084/m9.figshare.c.4792053
URL https://dx.doi.org/10.1186/s13058-019-1235-8
URL https://dx.doi.org/10.6084/m9.figshare.c.4792053.v1
URL https://dx.doi.org/10.6084/m9.figshare.c.4792053
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Author Fernandez-Garcia, Daniel
Author Hills, Allison
Author Page, Karen
Author Hastings, Robert
Author Toghill, Bradley
Author Goddard, Kate
Author Ion, Charlotte
Author Ogle, Olivia
Author Boydell, Anna
Author Gleason, Kelly
Author Rutherford, Mark
Author Lim, Adrian
Author Guttery, David
Author R. Coombes
Author Shaw, Jacqueline
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Collected From Datacite
Hosted By figshare
Publication Date 2019-12-20
Publisher Springer Science and Business Media LLC
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Source https://science-innovation-policy.openaire.eu/search/dataset?datasetId=dedup_wf_001::a54e7de1b3418a8543a769e396d357a7
Author jsonws_user
Last Updated 14 January 2021, 13:34 (CET)
Created 14 January 2021, 13:34 (CET)