Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads
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http://data.d4science.org/ctlg/RISIS2OpenData/dedup_wf_001--944626644d36d9a7d92ece0c13b9a47e |
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Identity
Access Modality
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Access Right | Open Access |
Attribution
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Author | Francesc Piferrer, 0000-0003-0903-4736 |
Author | Marco Antonio Imués-Figueroa, 0000-0002-7607-540X |
Author | Laia Ribas, 0000-0001-5538-6236 |
Contributor | Ministerio de Economía y Competitividad (España) |
Publishing
Field | Value |
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Collected From | Europe PubMed Central; PubMed Central; Digital.CSIC; ORCID; UnpayWall; Datacite; DOAJ-Articles; Crossref; Spiral - Imperial College Digital Repository; Microsoft Academic Graph |
Hosted By | Europe PubMed Central; Digital.CSIC; Epigenetics & Chromatin; Spiral - Imperial College Digital Repository |
Publication Date | 2017-12-01 |
Publisher | BioMed Central |
Additional Info
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Country | United Kingdom; Spain |
Description | [Results] Early treatment with 5-aza-dC altered embryonic development, delayed hatching and increased teratology and mortality, as expected. The most striking result, however, was an increase in the number of females, suggesting that alterations induced by 5-aza-dC treatment can affect sexual development as well. Results were confirmed when treatment coincided with gonadal development. In addition, we also found that the adult gonadal transcriptome of 5-aza-dC-exposed females included significant changes in the expression of key reproduction-related genes (e.g. cyp11a1, esr2b and figla), and that several pro-female-related pathways such as the Fanconi anaemia or the Wnt signalling pathways were downregulated. Furthermore, an overall inhibition of genes implicated in epigenetic regulatory mechanisms (e.g. dnmt1, dicer, cbx4) was also observed. |
Description | [Conclusions] Taken together, our results indicate that treatment with a DNA methylation inhibitor can also alter the sexual development in zebrafish, with permanent alterations of the adult gonadal transcriptome, at least in females. Our results show the importance of DNA methylation for proper control of sexual development, open new avenues for the potential control of sex ratios in fish (aquaculture, population control) and call attention to possibly hidden long-term effects of dnmt therapy when used, for example, in the treatment of prepuberal children affected by some types of cancer |
Description | Work supported by Ministry of Economy and Competitiveness (MEC) grants from Spanish government (“EpiFarm”: AGL2013-41047-R) and Aquagenomics (CDS2007-0002) to FP LR was supported by an Epifarm contract |
Description | Peer reviewed |
Language | English |
Resource Type | Article; UNKNOWN |
system:type | publication |
Management Info
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Source | https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::944626644d36d9a7d92ece0c13b9a47e |
Author | jsonws_user |
Last Updated | 25 December 2020, 05:36 (CET) |
Created | 25 December 2020, 05:36 (CET) |