Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis

Abstract Background Several studies have focused on the association between KIF1B rs17401966 polymorphism and susceptibility to hepatitis B virus-related (HBV-related) hepatocellular carcinoma (HCC), but the conclusions have been inconsistent. We have conducted this updated meta-analysis to explore the association between KIF1B rs17401966 polymorphism and HCC susceptibility. Methods Eligible studies were identified through systematic searches in PubMed, OVID, ISI Web of Science, Chinese National Knowledge Infrastructure, and Wanfang databases. The quality of evidence was systematically assessed by use of the Newcastle-Ottawa Scale for case control studies in meta-analyses. Results Ten studies containing 18 independent case-control studies were included. The results revealed a significant association between KIF1B rs17401966 polymorphism and susceptibility to HCC under a random-effect allelic model (OR = 0.85, 95% CI 0.76–0.94, P = 0.003); HBV-positive subgroup (OR = 0.82, 95% CI 0.72–0.95, P = 0.007); and Chinese-subgroup (OR = 0.82, 95% CI 0.72–0.93, P = 0.002). Conclusions G-allele appears to be a protective allele of KIF1B for HCC, especially in HBV-positive and Chinese populations. More well-designed studies with larger sample size and various ethnic groups and risk factors are needed to establish that KIF1B rs17401966 polymorphism is significantly associated with risk of HCC.

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PID https://www.doi.org/10.6084/m9.figshare.c.4460624.v1
PID https://www.doi.org/10.6084/m9.figshare.c.4460624
URL http://dx.doi.org/10.6084/m9.figshare.c.4460624.v1
URL http://dx.doi.org/10.6084/m9.figshare.c.4460624
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Author Luo, Ying-Ying
Author Hong-Peng Zhang
Author Ai-Long Huang
Author Jie-Li Hu
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Collected From Datacite
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Publication Date 2019-01-01
Publisher Figshare
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Language UNKNOWN
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keyword FOS: Biological sciences
keyword FOS: Mathematics
system:type other
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Source https://science-innovation-policy.openaire.eu/search/other?orpId=dedup_wf_001::93e2b5f962602a518a1cc7e9da884ca9
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Last Updated 20 December 2020, 00:09 (CET)
Created 20 December 2020, 00:09 (CET)