Additional file 1: of Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers

Figure S1. Unweighted Unifrac distances between tumor and normal-associated microbiota in dMMR and pMMR. Figure S2. Venn diagram highlighting number of microbes that overlap between tumor and normal samples in relation to MMR status (dMMR = red font, pMMR = green font, red circles = tumor samples, blue circles =normal samples). Figure S3. Microbes significantly enriched in tumor as compared to normal samples (colon tissue and mucosa) in individuals with dMMR CRC: a) Bacteroides fragilis and b) Fusobacterium nucleatum. Figure S4. Differentially abundant OTUs between patient-matched tumor and normal samples in individuals with dMMR CRC from an independent cohort. Table S1. Table S1: List of PATRIC model IDs and associated sOTUs. Table S2. Microbes identified as differentially abundant in tumor as compared to normal samples (tissue and mucosa) from individuals with dMMR or pMMR CRC. Table S3. sOTUs enriched in tumor samples (colon tissue and mucosa) as compared to normal adjacent samples in individuals with dMMR CRC. Table S4. sOTUs enriched in tumor samples (colon tissue and mucosa) as compared to normal adjacent samples in individuals with pMMR CRC. Table S5. sOTUs enriched in the proximal or distal colon (colon tissue and mucosa) of individuals with dMMR CRC. Table S6. sOTUs enriched in the proximal or distal colon (colon tissue and mucosa) of individuals with pMMR CRC. Table S7. Differentially abundant microbes in individuals with dMMR CRC from an independent cohort. Table S8. Differentially abundant microbes in individuals with pMMR CRC from an independent cohort. (PDF 2790 kb)

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Author Hale, Vanessa
Author Jeraldo, Patricio
Author Chen, Jun
Author Mundy, Michael
Author Yao, Janet
Author Sambhawa Priya
Author Keeney, Gary
Author Lyke, Kelly
Author Ridlon, Jason
Author White, Bryan
Author French, Amy
Author Thibodeau, Stephen
Author Diener, Christian
Author Osbaldo Resendis-Antonio
Author Gransee, Jaime
Author Tumpa Dutta
Author Xuan-Mai Petterson
Author Jaeyun Sung
Author Blekhman, Ran
Author Boardman, Lisa
Author Larson, David
Author Nelson, Heidi
Author Chia, Nicholas
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Publication Date 2018-10-31
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keyword FOS: Chemical sciences
keyword FOS: Biological sciences
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::4e36936fddf7ea3c1567fba2c523a98b
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Last Updated 22 December 2020, 13:35 (CET)
Created 22 December 2020, 13:35 (CET)