Drug development for noise-induced hearing loss

[Introduction] Excessive exposure to noise is a common occurrence that contributes to approximately 50% of the non-genetic hearing loss cases. Researchers need to develop standardized preclinical models and identify molecular targets to effectively develop prevention and curative therapies.

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PID https://www.doi.org/10.6084/m9.figshare.12859802
PID https://www.doi.org/10.6084/m9.figshare.12859802.v1
PID https://www.doi.org/10.1080/17460441.2020.1806232
PID handle:10261/218936
URL https://www.tandfonline.com/doi/pdf/10.1080/17460441.2020.1806232
URL http://dx.doi.org/10.1080/17460441.2020.1806232
URL http://hdl.handle.net/10261/218936
URL http://dx.doi.org/10.6084/m9.figshare.12859802
URL http://dx.doi.org/10.6084/m9.figshare.12859802.v1
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Author Varela-Nieto, Isabel
Author Murillo-Cuesta, Silvia
Author Calvino, Miryam
Author Cediel, Rafael
Author Lassaletta, Luis
Contributor European Commission
Contributor Comunidad de Madrid
Contributor Ministerio de Ciencia, Innovación y Universidades (España)
Contributor Agencia Estatal de Investigación (España)
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Collected From Digital.CSIC; Datacite; figshare; Crossref
Hosted By Digital.CSIC; Expert Opinion on Drug Discovery; figshare
Publication Date 2020-08-25
Publisher Taylor & Francis
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Country Spain
Description [Areas covered] In this review, the authors discuss the many facets of human noise-induced pathology, and the primary experimental models for studying the basic mechanisms of noise-induced damage, making connections and inferences among basic science studies, preclinical proofs of concept and clinical trials.
Description [Expert opinion] Whilst experimental research in animal models has helped to unravel the mechanisms of noise-induced hearing loss, there are often methodological variations and conflicting results between animal and human studies which make it difficult to integrate data and translate basic outcomes to clinical practice. Standardization of exposure paradigms and application of -omic technologies will contribute to improving the effectiveness of transferring newly gained knowledge to clinical practice.
Description This work was supported by the grants Multi Target and View FEDER/CM-B2017/BMD-3688 from the Consejería de Educación e Investigación, Comunidad de Madrid and MINECO/FEDER SAF2017-86107-R from the Ministerio de Economía, Industria y Competitividad, Gobierno de España.
Description Peer reviewed
Language UNKNOWN
Resource Type Other literature type; Article
keyword FOS: Health sciences
keyword FOS: Biological sciences
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::3b37d7a00f56574fbd74ed3ff5809933
Author jsonws_user
Last Updated 25 December 2020, 18:14 (CET)
Created 25 December 2020, 18:14 (CET)