dedup_wf_001--2024910a68cd986b5f7a7319a61f2080

Picrorhizae Rhizoma as a hepatoprotective herb, has been applied for thousands of years, and picroside was proved to be its active constituent. In this study, twelve derivatives of picroside were synthesized and the hepatoprotective activity of the derivatives was evaluated on SMMC-7721 cells. Six out of the derivatives had shown a better protective effect on H2O2-induced SMMC-7221 cells than picroside, and the activity of two derivatives (2 and 4) was stronger than that of the reference compound, silybin. Compound 2 shown the strongest protective effect (EC50 = 6.064 ± 1.295 μM).

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PID https://www.doi.org/10.6084/m9.figshare.7314569.v1
URL http://dx.doi.org/10.6084/m9.figshare.7314569.v1
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Access Right Open Access
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Author Han, Hua
Author Li, ZhengQing
Author ZhenLei Gao
Author Yin, Xin
Author PeiLiang Dong
Author BingYou Yang
Author HaiXue Kuang
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Collected From figshare; Datacite
Hosted By figshare
Publication Date 2018-11-08
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Language UNKNOWN
Resource Type Other literature type
keyword FOS: Chemical sciences
keyword FOS: Biological sciences
keyword FOS: Health sciences
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::2024910a68cd986b5f7a7319a61f2080
Author jsonws_user
Last Updated 27 December 2020, 02:55 (CET)
Created 27 December 2020, 02:55 (CET)