Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.

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PID https://www.doi.org/10.6084/m9.figshare.12851024
PID https://www.doi.org/10.6084/m9.figshare.12851024.v1
PID https://www.doi.org/10.1080/01658107.2020.1760891
PID urn:urn:nbn:nl:ui:31-1d6c5edb-fdee-4c6d-8b81-4ed3bc392b08
URL http://www.scopus.com/inward/record.url?scp=85086173129&partnerID=8YFLogxK
URL http://dx.doi.org/10.6084/m9.figshare.12851024
URL https://research.vumc.nl/en/publications/1d6c5edb-fdee-4c6d-8b81-4ed3bc392b08
URL https://academic.microsoft.com/#/detail/3043693244
URL http://dx.doi.org/10.1080/01658107.2020.1760891
URL https://www.tandfonline.com/doi/pdf/10.1080/01658107.2020.1760891
URL https://www.tandfonline.com/doi/full/10.1080/01658107.2020.1760891
URL https://research.vumc.nl/en/publications/multirater-validation-of-peripapillary-hyperreflective-ovoid-mass
URL http://dx.doi.org/10.6084/m9.figshare.12851024.v1
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Author Axel Petzold, 0000-0002-0344-9749
Author Valerie Biousse
Author Lulu Bursztyn
Author Fiona Costello
Author Alison Crum
Author Kathleen Digre
Author Clare Fraser, 0000-0002-0379-7743
Author J. Alex Fraser
Author Bradley Katz
Author Neringa Jurkute
Author Nancy Newman
Author Jette Lautrup-Battistini
Author Mitchell Lawlor
Author Petra Liskova
Author Birgit Lorenz
Author Lasse Malmqvist
Author Jason Peragallo
Author Patrick Sibony
Author Prem Subramanian
Author Robert Rejdak, 0000-0003-3321-2723
Author Katarzyna Nowomiejska
Author Valerie Touitou
Author Judith Warner
Author Marianne Wegener
Author Sui Wong
Author Patrick Yu-Wai-Man
Author Steffen Hamann
Contributor Neurology
Contributor Amsterdam Public Health - Methodology
Contributor Amsterdam Public Health - Mental Health
Contributor Amsterdam Neuroscience - Neuroinfection and -inflammation
Contributor Ophthalmology
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Collected From Datacite; figshare; NARCIS; Crossref; Microsoft Academic Graph
Hosted By Universiteit van Amsterdam Digital Academic Repository; figshare; NARCIS; Neuro-Ophthalmology
Publication Date 2020-01-01
Publisher Taylor & Francis
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Country Netherlands
Language UNKNOWN
Resource Type Other literature type; Article
keyword FOS: Mathematics
keyword FOS: Biological sciences
system:type publication
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Source https://science-innovation-policy.openaire.eu/search/publication?articleId=dedup_wf_001::1c355b50995ac73363897bcf694cfe61
Author jsonws_user
Last Updated 26 December 2020, 18:11 (CET)
Created 26 December 2020, 18:11 (CET)