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18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse ...
Abstract Background Positron emission tomography (PET) using translocator protein (TSPO) ligands has been used to detect neuroinflammatory processes in neurological disorders,... -
A retrospective study of the clinical phenotype and predictors of survival in...
Abstract Background Little is known about the clinical phenotype of amyotrophic lateral sclerosis (ALS) in non-Caucasian populations. Here, we aimed to describe the clinical... -
Prevalence and characteristics of older adults with a persistent death wish w...
Abstract Background Some older persons develop a persistent death wish without being severely ill, often referred to as “completed life” or “tiredness of life”. In the... -
Involvement of ABC-transporters and acyltransferase 1 in intracellular choles...
Abstract Background Understanding pathogenic mechanisms is imperative for developing novel treatment to the tuberculosis, an important public health burden worldwide. Recent... -
Serum amyloid A primes microglia for ATP-dependent interleukin-1β release
Abstract Background Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A... -
An analysis of SPECT/CT non-visualization of sentinel lymph nodes in renal tu...
Abstract Background Sentinel lymph node biopsy (SLNB) after intratumoral injection of 99mTc labeled nanocolloid and imaging with scintigraphy and SPECT/CT in renal tumors is... -
Stage 4 s neuroblastoma: features, management and outcome of 268 cases from t...
Abstract Background Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We... -
The application of FTIR microspectroscopy in a non-invasive and non-destructi...
Abstract The potential of Fourier Transform Infrared (FTIR) microspectroscopy, to inform the study and conservation of mineralised excavated textiles is discussed, highlighted... -
Helios + Regulatory T cell frequencies are correlated with control of viral r...
Abstract Background The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation.... -
Cortical vein thrombosis in adult patients of cerebral venous sinus thrombosi...
Abstract Background Cortical vein thrombosis (CVT) receives little attention in adult patients with cerebral venous sinus thrombosis (CVST). This study aimed to investigate the... -
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels...
Abstract Background There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of... -
Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
The clinical practice guideline for the management of ARDS in Japan
Abstract Background The Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine provide here a clinical practice guideline for the... -
Unique patterns of lower respiratory tract microbiota are associated with inf...
Abstract Background The lung microbiome maintains the homeostasis of the immune system within the lungs. In acute respiratory distress syndrome (ARDS), the lung microbiome is... -
Integrative assessment of brain and bone invasion in meningioma patients
Abstract Background Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain... -
The validity of pediatric cancer diagnoses in a population-based general canc...
Abstract Background Data from population-based cancer registries are increasingly used to conduct research and guide policy. However, few validation studies of cancer registry... -
A fast and cost-effective microsampling protocol incorporating reduced animal...
Abstract Background The transcriptional regulation that occurs in malaria parasites during the erythrocytic stages of infection can be studied in vivo with rodent malaria... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
First regulatory inspections measuring adherence to Good Pharmacy Practices i...
Abstract Background Since its inception, the Uganda National Drug Authority (NDA) has regularly inspected private sector pharmacies to monitor adherence to Good Pharmacy... -
Differential expression of E-type prostanoid receptors 2 and 4 in microglia s...
Abstract Background Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic...
