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Integrative assessment of brain and bone invasion in meningioma patients
Abstract Background Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain... -
Suspicion of respiratory tract infection with multidrug-resistant Enterobacte...
Abstract Background Multidrug-resistant (MDR) infections are a serious concern for children admitted to the Paediatric Intensive Care Unit (PICU). Tracheal colonization with MDR... -
Local measles vaccination gaps in Germany and the role of vaccination providers
Abstract Background Measles elimination in Europe is an urgent public health goal, yet despite the efforts of its member states, vaccination gaps and outbreaks occur. This study... -
Tigecycline in critically ill patients on continuous renal replacement therap...
Abstract Background Tigecycline is a vital antibiotic treatment option for infections caused by multiresistant bacteria in the intensive care unit (ICU). Acute kidney injury... -
Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation o...
Abstract To investigate the genetics of late-onset myasthenia gravis (LOMG), we conducted a genome-wide association study imputation of >6 million single nucleotide... -
Comparison of treatment response, remission rate and drug adherence in polyar...
Background Treatment response, remission rates and compliance in patients with polyarticular juvenile idiopathic arthritis (polyJIA) treated with adalimumab, etanercept, or... -
Open-label, multicenter, single-arm phase II DeCOG-study of ipilimumab in pre...
Abstract Background Ipilimumab is an approved immunotherapy that has shown an overall survival benefit in patients with cutaneous metastatic melanoma in two phase III trials. As... -
CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
Abstract Background Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe... -
Long-term safety and efficacy of vismodegib in patients with advanced basal c...
Abstract Background In the primary analysis of the ERIVANCE BCC trial, vismodegib, the first US Food and Drug Administration–approved Hedgehog pathway inhibitor, showed... -
A randomised, double-blind clinical phase II trial of the efficacy, safety, t...
Abstract Background The clinical development of a single encounter treatment for uncomplicated malaria has the potential to significantly improve the effectiveness of... -
Inpatient gradual diagnostics and its relevance for determining treatment str...
Abstract Background Identifying patients who will benefit from spine surgery is still a challenge. This is especially the case when patients’ complaints and medical history,...
