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Glycaemic control targets after traumatic brain injury: a systematic review a...
Abstract Background Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-analysis of randomised controlled trials... -
Twenty-five years of optical coherence tomography: the paradigm shift in sens...
Optical coherence tomography (OCT) has become one of the most successful optical technologies implemented in medicine and clinical practice mostly due to the possibility of... -
Ethical aspects of sudden cardiac arrest research using observational data: a...
Abstract Sudden cardiac arrest (SCA) accounts for half of all cardiac deaths in Europe. In recent years, large-scale SCA registries have been set up to enable observational... -
A systematic review to investigate the measurement properties of goal attainm...
Abstract Background One of the main challenges for drug evaluation in rare diseases is the often heterogeneous course of these diseases. Traditional outcome measures may not be... -
Risk factors for delirium after on-pump cardiac surgery: a systematic review
Abstract Introduction As evidence-based effective treatment protocols for delirium after cardiac surgery are lacking, efforts should be made to identify risk factors for... -
The COMET Handbook: Version 1.0
Abstract The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to... -
Assessment of fluid responsiveness in spontaneously breathing patients: a sys...
Patients who increase stoke volume or cardiac index more than 10 or 15% after a fluid challenge are usually considered fluid responders. Assessment of fluid responsiveness prior... -
Systematic review of clinical practice guidelines recommendations about prima...
Abstract Background Clinical care for older adults is complex and represents a growing problem. They are a diverse patient group with varying needs, frequent presence of... -
Rational and design of an individual participant data meta-analysis of spinal...
Abstract Background Chronic low back pain (LBP) is the leading cause of pain and disability, resulting in a major socioeconomic impact. The Cochrane Review which examined the... -
Risk factors for necrotizing enterocolitis in neonates: a systematic review o...
Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into... -
The influence of pregnancy on the pharmacokinetic properties of artemisinin c...
Abstract Background Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based... -
Performance of critical care prognostic scoring systems in low and middle-inc...
Abstract Background Prognostic modelsâ used in critical care medicine for mortality predictions, for benchmarking and for illness stratification in clinical trialsâ have been... -
Socio-cultural determinants of physical activity across the life course: A 'D...
Abstract Objective Regular physical activity (PA) reduces the risk of disease and premature death. Knowing factors associated with PA might help reducing the disease and...
