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Cognitive functioning in patients with classical galactosemia: a systematic r...
Abstract Background Patients with the metabolic disorder classical galactosemia suffer from long-term complications despite a galactose-restricted diet, including a below... -
Use of theory to plan or evaluate guideline implementation among physicians: ...
Abstract Background Guidelines support health care decision-making and high quality care and outcomes. However, their implementation is sub-optimal. Theory-informed, tailored... -
Microcirculatory perfusion disturbances following cardiopulmonary bypass: a s...
Abstract Background Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary... -
Rational and design of an individual participant data meta-analysis of spinal...
Abstract Background Chronic low back pain (LBP) is the leading cause of pain and disability, resulting in a major socioeconomic impact. The Cochrane Review which examined the... -
Risk factors for necrotizing enterocolitis in neonates: a systematic review o...
Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into... -
Long-read sequencing uncovers a complex transcriptome topology in varicella z...
Abstract Background Varicella zoster virus (VZV) is a human pathogenic alphaherpesvirus harboring a relatively large DNA molecule. The VZV transcriptome has already been... -
Transcranial direct current stimulation (tDCS) for improving capacity in acti...
Abstract Background Transcranial Direct Current Stimulation (tDCS) is an emerging approach for improving capacity in activities of daily living (ADL) and upper limb function... -
What are effective strategies for the implementation of care bundles on ICUs:...
Abstract Background Care bundles have proven to be effective in improving clinical outcomes. It is not known which strategies are the most effective to implement care bundles. A... -
Systematic mapping review of the factors influencing physical activity and se...
Abstract Background Physical activity and sedentary behaviour are associated with health and wellbeing. Studies indicate that ethnic minority groups are both less active and... -
The influence of pregnancy on the pharmacokinetic properties of artemisinin c...
Abstract Background Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based... -
Is HPA axis reactivity in childhood gender-specific? A systematic review
Abstract Background In adults, hypothalamus–pituitary–adrenal (HPA) axis activity shows sexual dimorphism, and this is thought to be a mechanism underlying sex-specific disease... -
SCORE-IT (Selecting Core Outcomes for Randomised Effectiveness trials In Type...
Abstract Background Outcomes measured in clinical trials should be meaningful to patients, healthcare professionals and researchers, yet there is heterogeneity in the outcomes... -
Performance of critical care prognostic scoring systems in low and middle-inc...
Abstract Background Prognostic modelsâ used in critical care medicine for mortality predictions, for benchmarking and for illness stratification in clinical trialsâ have been... -
Socio-cultural determinants of physical activity across the life course: A 'D...
Abstract Objective Regular physical activity (PA) reduces the risk of disease and premature death. Knowing factors associated with PA might help reducing the disease and... -
Assessing the effect of interventions for axial spondyloarthritis according t...
Abstract The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record...