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Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and ...
Abstract Background A pre-specified meta-analysis of cardiovascular (CV) events from 21 phase 2b/3 dapagliflozin clinical trials was undertaken to characterise the CV profile of... -
The regulatory effect of microRNA-21a-3p on the promotion of telocyte angioge...
Abstract Background Telocytes (TCs) are newly identified interstitial cells that participate in tissue protection and repair. The present study investigated the mechanisms... -
Cohort profile: the German Diabetes Study (GDS)
Abstract Background The German Diabetes Study (GDS) is a prospective longitudinal cohort study describing the impact of subphenotypes on the course of the disease. GDS aims at... -
A kinetic metabolic study of lipid production in Chlorella protothecoides und...
Abstract Background Microalgae have been proposed as potential platform to produce lipid-derived products, such as biofuels. Knowledge on the intracellular carbon flow... -
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive pro...
Abstract Background Harnessing the actions of the resolvin pathways has the potential for the treatment of a wide range of conditions associated with overt inflammatory... -
Modeling hormonal and inflammatory contributions to preterm and term labor us...
Abstract Background Preterm birth is now recognized as the primary cause of infant mortality worldwide. Interplay between hormonal and inflammatory signaling in the uterus... -
miR-375 mediates the CRF signaling pathway to regulate catecholamine biosynth...
Corticotropin-releasing-factor (CRF) is a key regulator of catecholamines (CATs) biosynthesis in the adrenal gland. Furthermore, miR-375 has been confirmed to be localized in... -
Glycine receptors expression in rat spinal cord and dorsal root ganglion in p...
Abstract Background Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in... -
Lingguizhugan decoction attenuates doxorubicin-induced heart failure in rats ...
Abstract Background Lingguizhugan decoction (LGZG), an ancient Chinese herbal formula, has been used to treat cardiovascular diseases in eastern Asia. We investigated whether... -
A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced In...
Abstract Studies imply that intestinal barrier dysfunction is a key contributor to morbid events associated with sepsis. Recently, the co-inhibitory molecule programmed... -
Association between pre-pregnancy body weight and dietary pattern with large-...
Abstract Background Both obesity and gestational diabetes (GDM) are associated with adverse outcomes. Diet during pregnancy impacts weight gain and fetal growth. Therefore, we... -
Transcriptional analysis of porcine intestinal mucosa infected with Salmonell...
Abstract Infected pork meat is an important source of non-typhoidal human salmonellosis. Understanding of molecular mechanisms involved in disease pathogenesis is important for... -
Coronary calcification as a predictor of cardiovascular mortality in advanced...
Abstract Background Patients with advanced chronic kidney disease (CKD) exhibit higher prevalence of coronary artery calcification (CaC) than general population. CaC has been... -
Randomized controlled studies on the efficacy of antiarthritic agents in inhi...
Abstract Background As an initial step in the development of a local therapeutic to treat osteoarthritis (OA), a number of agents were tested for their ability to block... -
Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chr...
Abstract Background Neuropathic pain belongs to chronic pain and is caused by the primary dysfunction of the somatosensory nervous system. Long noncoding RNAs (lncRNAs) have... -
Increased circulating resistin levels in early-onset breast cancer patients o...
Abstract Background Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast... -
Diet-related greenhouse gas emissions assessed by a food frequency questionna...
Abstract Background The current food system generates about 25 % of total greenhouse gas emissions (GHGE), including deforestation, and thereby substantially contributes to the... -
Developmental basis for intestinal barrier against the toxicity of graphene o...
Abstract Background Intestinal barrier is crucial for animals against translocation of engineered nanomaterials (ENMs) into secondary targeted organs. However, the molecular... -
Base excess and hematocrit predict response to indomethacin in very low birth...
Abstract Background The treatment of patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants remains a challenge. The ability to predict which infants will...
