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The COMET Handbook: Version 1.0
Abstract The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to... -
Systematic review of clinical practice guidelines recommendations about prima...
Abstract Background Clinical care for older adults is complex and represents a growing problem. They are a diverse patient group with varying needs, frequent presence of... -
Rational and design of an individual participant data meta-analysis of spinal...
Abstract Background Chronic low back pain (LBP) is the leading cause of pain and disability, resulting in a major socioeconomic impact. The Cochrane Review which examined the... -
Risk factors for necrotizing enterocolitis in neonates: a systematic review o...
Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into... -
The influence of pregnancy on the pharmacokinetic properties of artemisinin c...
Abstract Background Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based... -
Performance of critical care prognostic scoring systems in low and middle-inc...
Abstract Background Prognostic modelsâ used in critical care medicine for mortality predictions, for benchmarking and for illness stratification in clinical trialsâ have been... -
Socio-cultural determinants of physical activity across the life course: A 'D...
Abstract Objective Regular physical activity (PA) reduces the risk of disease and premature death. Knowing factors associated with PA might help reducing the disease and...
