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Golgi tethering factor golgin-97 suppresses breast cancer cell invasiveness b...
Abstract Background Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the... -
Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their pro...
Abstract Background Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or... -
Excessive carbohydrate consumption and body mass index: the risk factors for ...
Abstract Background Prader-Willi syndrome (PWS) is commonly associated with severe obesity and type 2 diabetes mellitus (T2DM) and is caused by excessive eating. Only very few... -
Development of gut inflammation in mice colonized with mucosa-associated bact...
Abstract Background Disturbances in the intestinal microbial community (i.e. dysbiosis) or presence of the microbes with deleterious effects on colonic mucosa has been linked to... -
Assessment of blood levels of heavy metals including lead and manganese in he...
Abstract Background Exposure to environmental heavy metals is common among African children. Although many of these metals are known neurotoxicants, to date, monitoring of this... -
Rice WRKY11 Plays a Role in Pathogen Defense and Drought Tolerance
Abstract Background Plants are frequently subjected to abiotic and biotic stresses, and WRKY proteins play a pivotal role in the response to such stress. OsWRKY11 is induced by... -
Integrative assessment of brain and bone invasion in meningioma patients
Abstract Background Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Resveratrol mediates mechanical allodynia through modulating inflammatory res...
Abstract Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting... -
Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squa...
Abstract Background Local resident normal fibroblasts (NFs) are the major source of cancer-associated fibroblasts (CAFs), which are distinguishable from NFs by their... -
Low levels of pyruvate induced by a positive feedback loop protects cholangio...
Abstract Background Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is... -
M1-like tumor-associated macrophages activated by exosome-transferred THBS1 p...
Abstract Background Treatment strategies targeting tumor-associated macrophages (TAMs) have been proposed in cancer areas. The functional alterations of macrophages in the... -
Identification of plasma microRNA expression changes in multiple system atrop...
Abstract MicroRNAs (miRNAs) are endogenous small (18–25 nt), single-stranded, non-coding RNAs that play key roles in post-transcriptional gene expression regulation. The... -
Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17...
Abstract Background Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs... -
The impact of disease severity on paradoxical association between body mass i...
Abstract Background Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation.... -
Amorphous silica nanoparticles induce malignant transformation and tumorigene...
Rapid development and deployment of engineered nanomaterials, such as amorphous silica nanoparticles (SiNPs) in various commercial and biomedical applications have raised... -
Whole blood microRNA markers are associated with acute respiratory distress s...
Abstract Background MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We... -
Transcriptomic data from two primary cell models stimulating human monocytes ...
Abstract Background Biological interpretation of DNA microarray data may differ depending on underlying assumptions and statistical tests of bioinformatics tools used. We used... -
Impact of radiographer immediate reporting of chest X-rays from general pract...
Abstract Background Diagnostic capacity and suboptimal logistics are consistently identified as barriers to timely diagnosis of cancer, especially lung cancer. Immediate chest... -
Isolation and identification of a TetR family protein that regulates the biod...
Abstract Biodesulfurization helps in removal of sulfur from organosulfur present in petroleum fractions. All microorganisms isolated to date harbor a desulfurization operon...
