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Genome-wide DNA methylation at birth in relation to in utero arsenic exposure...
Abstract Background In utero arsenic exposure may alter fetal developmental programming by altering DNA methylation, which may result in a higher risk of disease in later life.... -
Reduced DNA methylation of the oxytocin receptor gene is associated with obse...
Abstract Background Oxytocin is an important neuromodulator involved in cognition and socio-emotional processing that exerts its central activities via oxytocin receptors.... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Variability of Uncrossmatched Blood Use by Helicopter EMS Programs in the Uni...
Study Objective: Some helicopter emergency medical services (HEMS) maintain an independent supply of blood for use during transport, although practice is variable and not well... -
Identification of plasma microRNA expression changes in multiple system atrop...
Abstract MicroRNAs (miRNAs) are endogenous small (18–25 nt), single-stranded, non-coding RNAs that play key roles in post-transcriptional gene expression regulation. The... -
Transcriptomic data from two primary cell models stimulating human monocytes ...
Abstract Background Biological interpretation of DNA microarray data may differ depending on underlying assumptions and statistical tests of bioinformatics tools used. We used... -
A novel transcription factor specifically regulates GH11 xylanase genes in Tr...
Abstract Background The filamentous fungus Trichoderma reesei is widely utilized in industry for cellulase production, but its xylanase activity must be improved to enhance the... -
Bursicon-α subunit modulates dLGR2 activity in the adult <i>Drosophila</i> me...
Bursicon is the main regulator of post molting and post eclosion processes during arthropod development. The active Bursicon hormone is a heterodimer of Burs-α and Burs-... -
Plasma levels of increased miR-195-5p correlates with the sFLT-1 levels in pr...
Although the role of soluble fms-like tyrosine kinase 1 (sFLT-1) in preeclampsia is well-established, the mechanism related to its synthesis remains poorly understood. We... -
Macrophage Migration Inhibitory Factor (MIF) Enzymatic Activity and Lung Cancer
Abstract The cytokine macrophage migration inhibitory factor (MIF) possesses unique tautomerase enzymatic activity, which contributes to the biological functional activity of... -
Cytosolic phospholipase A2 (cPLA2) IVA as a potential signature molecule in c...
Abstract Background Smoking is one of the leading causes of millions of deaths worldwide. During cigarette smoking, most affected and highly exposed cells are the alveolar... -
Expression of ACE2 and a viral virulence-regulating factor CCN family member ...
Abstract It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS)... -
The effects of green cardamom on blood glucose indices, lipids, inflammatory ...
Abstract Background The relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of... -
Aberrant activation of NF-κB signaling in mammary epithelium leads to abnorma...
Abstract Background Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though... -
Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation ...
Abstract Background High rates of recurrence and metastasis are the major cause of the poor outcomes for patients with lung cancer. In previous research, we have demonstrated... -
Major differential gene regulation in Coxiella burnetii between in vivo and i...
Abstract Background Coxiella burnetii is the causative agent of the zoonotic disease Q fever. As it is an intracellular pathogen, infection by C. burnetii requires adaptation to... -
Sex-specific IL-6-associated signaling activation in ozone-induced lung infla...
Abstract Background Acute ozone (O3) exposure has known deleterious effects on the respiratory system and has been linked with respiratory disease and infection. Inflammatory... -
Construction of a trifunctional cellulase and expression in Saccharomyces cer...
Abstract Background Cellulose is the most important component of lignocellulose, and its degradation requires three different types of enzymes to act synergistically. There have... -
Subfunctionalization of peroxisome proliferator response elements accounts fo...
Abstract Background In the duplication-degeneration-complementation (DDC) model, a duplicated gene has three possible fates: it may lose functionality through the accumulation... -
Hedgehog signalling does not stimulate cartilage catabolism and is inhibited ...
Abstract Background In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading enzymes, MMP-13...
