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Transcriptomic data from two primary cell models stimulating human monocytes ...
Abstract Background Biological interpretation of DNA microarray data may differ depending on underlying assumptions and statistical tests of bioinformatics tools used. We used... -
Association of four imprinting disorders and ART
Abstract Background Human-assisted reproductive technologies (ART) are a widely accepted treatment for infertile couples. At the same time, many studies have suggested the... -
Impact of radiographer immediate reporting of chest X-rays from general pract...
Abstract Background Diagnostic capacity and suboptimal logistics are consistently identified as barriers to timely diagnosis of cancer, especially lung cancer. Immediate chest... -
A novel transcription factor specifically regulates GH11 xylanase genes in Tr...
Abstract Background The filamentous fungus Trichoderma reesei is widely utilized in industry for cellulase production, but its xylanase activity must be improved to enhance the... -
Genome-wide transcriptional adaptation to salt stress in Populus
Abstract Background Adaptation to abiotic stresses is crucial for the survival of perennial plants in a natural environment. However, very little is known about the underlying... -
High expression of Linc00959 predicts poor prognosis in breast cancer
Abstract Background Accumulating studies have focused on the oncogenic roles of the newly identified lncRNAs in human cancers. The aim of this study was to examine the... -
Isolation and identification of a TetR family protein that regulates the biod...
Abstract Biodesulfurization helps in removal of sulfur from organosulfur present in petroleum fractions. All microorganisms isolated to date harbor a desulfurization operon... -
SOX2 interferes with the function of CDX2 in bile acid-induced gastric intest...
Abstract Background Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer. Both animal and clinical studies have revealed that bile acid reflux and... -
ERα-36 regulates progesterone receptor activity in breast cancer
Abstract Background Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR),... -
Evaluation of an online, real-time, soft-photon ionisation time-of-flight mas...
Abstract Mainstream tobacco smoke is a complex and dynamic aerosol, consisting of particulate and vapour phases. Most approaches to determine mainstream smoke toxicant yields... -
Bursicon-α subunit modulates dLGR2 activity in the adult <i>Drosophila</i> me...
Bursicon is the main regulator of post molting and post eclosion processes during arthropod development. The active Bursicon hormone is a heterodimer of Burs-α and Burs-... -
Association of 5p15.2 and 15q14 with high myopia in Tujia and Miao Chinese po...
Abstract Background The polymorphisms rs6885224 and rs634990 have been reported to be associated with high myopia in many populations. As there is still no report on whether... -
Plasma levels of increased miR-195-5p correlates with the sFLT-1 levels in pr...
Although the role of soluble fms-like tyrosine kinase 1 (sFLT-1) in preeclampsia is well-established, the mechanism related to its synthesis remains poorly understood. We... -
Genome-wide recruitment profiling of transcription factor Crz1 in response to...
Abstract Background Exposure of the budding Saccharomyces cerevisiae to an alkaline environment produces a robust transcriptional response involving hundreds of genes. Part of... -
Molecular mechanism of seed dormancy release induced by fluridone compared wi...
Abstract Background Notopterygium incisum is an important Chinese medicinal plant. Its mature seeds have underdeveloped embryos and are physiological dormant. We found the seeds... -
A prognostic CpG score derived from epigenome-wide profiling of tumor tissue ...
Abstract Background Results of previous studies on the association of the CpG island methylator phenotype (CIMP) with colorectal cancer (CRC) prognosis were inconsistent and... -
Distinct core promoter codes drive transcription initiation at key developmen...
Abstract Background Development is largely driven by transitions between transcriptional programs. The initiation of transcription at appropriate sites in the genome is a key... -
Pathway activity profiling of growth factor receptor network and stemness pat...
Abstract Background Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for... -
Macrophage Migration Inhibitory Factor (MIF) Enzymatic Activity and Lung Cancer
Abstract The cytokine macrophage migration inhibitory factor (MIF) possesses unique tautomerase enzymatic activity, which contributes to the biological functional activity of... -
Cytosolic phospholipase A2 (cPLA2) IVA as a potential signature molecule in c...
Abstract Background Smoking is one of the leading causes of millions of deaths worldwide. During cigarette smoking, most affected and highly exposed cells are the alveolar...
