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Golgi tethering factor golgin-97 suppresses breast cancer cell invasiveness b...
Abstract Background Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the... -
Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
CellTag Indexing: genetic barcode-based sample multiplexing for single-cell g...
Abstract High-throughput single-cell assays increasingly require special consideration in experimental design, sample multiplexing, batch effect removal, and data... -
Low levels of pyruvate induced by a positive feedback loop protects cholangio...
Abstract Background Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is... -
LncRNA RP11-436H11.5, functioning as a competitive endogenous RNA, upregulate...
Abstract Background Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in tumorigenesis. Here, we report a novel lncRNA, RP11-436H11.5, that... -
CIDR: Ultrafast and accurate clustering through imputation for single-cell RN...
Abstract Most existing dimensionality reduction and clustering packages for single-cell RNA-seq (scRNA-seq) data deal with dropouts by heavy modeling and computational... -
Highly active promoters and native secretion signals for protein production d...
Abstract Background The filamentous ascomycete Aspergillus niger is used in many industrial processes for the production of enzymes and organic acids by batch and fed-batch... -
Cytosolic phospholipase A2 (cPLA2) IVA as a potential signature molecule in c...
Abstract Background Smoking is one of the leading causes of millions of deaths worldwide. During cigarette smoking, most affected and highly exposed cells are the alveolar... -
Analysis of the role of thrombomodulin in all-trans retinoic acid treatment o...
Abstract Background Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and... -
Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predi...
Abstract Background The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid... -
Genome-wide characterization of human L1 antisense promoter-driven transcripts
Abstract Background Long INterspersed Element-1 (LINE-1 or L1) is the only autonomously active, transposable element in the human genome. L1 sequences comprise approximately 17... -
Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis...
Abstract Background Long noncoding RNAs (lncRNAs) have been indicated to play critical roles in cancer development and progression. LncRNA HOXD cluster antisense RNA1 (HOXD-AS1)... -
Pancreatic cancer-initiating cell exosome message transfer into noncancer-ini...
Abstract Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed,... -
Hemodynamic impacts of flow diverter devices on the ophthalmic artery
Abstract Background Flow diverter devices are increasingly used for endovascular treatment of internal carotid artery aneurysms. Treatment of ophthalmic segment aneurysms with... -
MIA-Sig: multiplex chromatin interaction analysis by signal processing and st...
Abstract The single-molecule multiplex chromatin interaction data are generated by emerging 3D genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets... -
Characteristics of therapeutic alliance in musculoskeletal physiotherapy and ...
Abstract Background Most conventional treatment for musculoskeletal conditions continue to show moderate effects, prompting calls for ways to increase effectiveness, including... -
Considerations for the use of Cre recombinase for conditional gene deletion i...
Abstract Background Despite a number of different transgenes that can mediate DNA deletion in the developing lens, each has unique features that can make a given transgenic line... -
Reduced expression of miR-146a in human bronchial epithelial cells alters neu...
Abstract Background The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress... -
Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogen...
Abstract Background We aimed to identify differentially expressed pseudogenes and explore their potential functions in four types of common gynecological malignancies (e.g.,... -
Genome-wide DNA methylation profile identified a unique set of differentially...
Abstract Background Oral squamous cell carcinoma (OSCC) is one of the common malignancies in Southeast Asia. Epigenetic changes, mainly the altered DNA methylation, have been...
