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Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
TSS seq based core promoter architecture in blood feeding Tsetse fly (Glossin...
Abstract Background Transcription initiation regulation is mediated by sequence-specific interactions between DNA-binding proteins (transcription factors) and cis-elements,... -
Reduced expression of miR-146a in human bronchial epithelial cells alters neu...
Abstract Background The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress... -
YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodeg...
Abstract Background Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a... -
Antibiotic-resistant Escherichia coli from retail poultry meat with different...
Abstract Background We sought to determine if the prevalence of antibiotic-resistant Escherichia coli differed across retail poultry products and among major production... -
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts b...
Abstract Background Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1). Cattle are the natural host of BLV where it... -
A novel ultra-sensitive method for the detection of FGFR3 mutations in urine ...
Abstract Background We have recently developed a highly accurate urine-based test, named Urodiag®, associating FGFR3 mutation and DNA methylation assays for recurrence... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Virulence factor landscape of a Staphylococcus aureus sequence type 45 strain...
Abstract Background We describe the virulence factors of a methicillin-sensitive Staphylococcus aureus sequence type (ST) 45 strain, MCRF184, (spa type t917), that caused severe... -
The caloric and sugar content of beverages purchased at different store-types...
Abstract Background Following the 2014 sugary drinks tax implementation in Mexico, promising reduction in the volume of purchases of taxed beverages were observed overall and at... -
Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia
Abstract Background A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis.... -
Karyotyping of circulating tumor cells for predicting chemotherapeutic sensit...
Abstract Background Aneuploidy of chromosome 8 in circulating tumor cells (CTCs) has been reported correlates with therapeutic efficacy and prognosis in patients with advanced... -
Nuclear localization of Newcastle disease virus matrix protein promotes virus...
Abstract Nuclear localization of paramyxovirus proteins is crucial for virus life cycle, including the regulation of viral replication and the evasion of host immunity. We... -
First evidence of a new simian adenovirus clustering with Human mastadenoviru...
Abstract Background Adenoviruses play an important role as human pathogens, though most infections are believed to be asymptomatic. The over 100 human adenovirus types are... -
Negligible risk of inducing resistance in Mycobacterium tuberculosis with sin...
Abstract Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the... -
Comparison of GeneXpert MRSA/SA ETA assay with semi-quantitative and quantita...
Abstract Introduction Staphylococcus aureus (S. aureus) is a common cause of ventilator-associated pneumonia. Rapid and accurate detection of lower respiratory tract... -
HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human g...
Abstract Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes.... -
Maternal blood contamination of collected cord blood can be identified using ...
Abstract Background Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a... -
Implementation and evaluation of a quality and safety tool for ambulatory str...
Abstract Background Strongyloidiasis is a common infection in Canadian migrants that can cause life-threatening hyperinfection in immunosuppressed hosts. We designed and... -
Inflammatory anemia-associated parameters are related to 28-day mortality in ...
Abstract Background Anemia is one of the most common complications of sepsis. Sepsis-related anemia is associated mainly with inflammation. We aimed to observe the changes in...
