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Sublingual microcirculation does not reflect red blood cell transfusion thres...
Abstract Purpose Hemoglobin (Hb) transfusion thresholds are established in intensive care units. A restrictive transfusion threshold (Hb 70–75 g/l) is recommended in septic... -
Determinants of difficulty in activities of daily living in ambulatory patien...
Abstract Background Patients undergoing hemodialysis (HD) have difficulty performing activities of daily living (ADL) compared to healthy people. ADL difficulty is an early... -
Statins and/or fibrates for diabetic retinopathy: a systematic review and met...
Abstract Evidence from observational studies have found a relationship between serum cholesterol and diabetic retinopathy (DR). Apart of the assumption that cholesterolemic... -
Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuate...
Abstract Background Kososan, a Kampo (traditional Japanese herbal) medicine, has been used for the therapy of depressive mood in humans. However, evidence for the antidepressant... -
SMARC-B1 deficient sinonasal carcinoma metastasis to the brain with next gene...
Abstract Background SMARCB1-deficient sinonasal carcinoma (SDSC) is an aggressive subtype of head and neck cancers that has a poor prognosis despite multimodal therapy. We... -
Effects of methylprednisolone on blood-brain barrier and cerebral inflammatio...
Abstract Background Cognitive dysfunction is a frequent complication to open-heart surgery. Cerebral inflammation caused by blood-brain barrier (BBB) dysfunction due to a... -
Expression of ACE2 and a viral virulence-regulating factor CCN family member ...
Abstract It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS)... -
Who is eligible for randomized trials? A comparison between the exclusion cri...
Abstract Background Randomized controlled trials are the gold standard for evaluating therapy; however, controversy exists regarding the applicability of such results to daily... -
Subunits of human condensins are potential therapeutic targets for cancers
Abstract The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits... -
Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospe...
Abstract Background Nonintubated chest trauma patients with fractured ribs admitted to the intensive care unit (ICU) are at risk for complications and may require invasive... -
Patterns of symptoms before a diagnosis of first episode psychosis: a latent ...
Abstract Background The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms... -
Contacting out-of-hours primary care or emergency medical services for time-c...
Abstract Background Out-of-hours (OOH) healthcare services in Western countries are often differentiated into out-of-hours primary healthcare services (OOH-PC) and emergency... -
Health professions’ students have an alarming prevalence of depressive sympto...
Abstract Background There is a need to better understand the depression phenomenon and to clarify why some students become depressed and others don’t. The purpose of this study... -
Vision-related quality of life considering both eyes: results from the German...
Abstract Purpose Most definitions of visual impairment focus on the status of the better-seeing eye only, but this approach might underestimate the influence of the worse-seeing... -
The lateral habenula is critically involved in histamine-induced itch sensation
Abstract Lateral habenula (LHb) is a brain region acting as a hub mediating aversive response against noxious, stressful stimuli. Growing evidences indicated that LHb modulates... -
Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and ...
Abstract Peripheral neuroinflammation is characterized by hematogenous mononuclear leukocyte infiltration into peripheral nerves. Despite significant clinical knowledge,... -
IGF-1 treatment causes unique transcriptional response in neurons from indivi...
Abstract Background Research evidence accumulated in the past years in both rodent and human models for autism spectrum disorders (ASD) have established insulin-like growth... -
Association of ARMS2 genotype with response to anti-vascular endothelial grow...
Abstract Background To investigate whether genetic risk variants for age-related macular degeneration (AMD) are associated with response to intravitreal anti-vascular... -
The number of tracheal intubation attempts matters! A prospective multi-insti...
Abstract Background The impact of multiple tracheal intubation (TI) attempts on outcomes in critically ill children with acute respiratory failure is not known. The objective of... -
A scalable cognitive behavioural program to promote healthy sleep during preg...
Abstract Background Poor sleep, including symptoms of insomnia are common during pregnancy and postpartum periods. Poor sleep during the perinatal period is linked to impaired...
