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Involvement of ABC-transporters and acyltransferase 1 in intracellular choles...
Abstract Background Understanding pathogenic mechanisms is imperative for developing novel treatment to the tuberculosis, an important public health burden worldwide. Recent... -
Serum amyloid A primes microglia for ATP-dependent interleukin-1β release
Abstract Background Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A... -
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels...
Abstract Background There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Differential expression of E-type prostanoid receptors 2 and 4 in microglia s...
Abstract Background Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic... -
Long-term Safety and Efficacy of Human-Induced Pluripotent Stem Cell (iPS) Gr...
Abstract The U.S. Food and Drug Administration recently approved phase I/II clinical trials for embryonic stem (ES) cell-based retinal pigmented epithelium (RPE)... -
iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated d...
Abstract Background Previous research indicated that nitric oxide synthase (NOS) is the key molecule for S-nitrosylation of ryanodine receptor 1 (RyR1) in DMD model mice (mdx... -
Transcriptomic data from two primary cell models stimulating human monocytes ...
Abstract Background Biological interpretation of DNA microarray data may differ depending on underlying assumptions and statistical tests of bioinformatics tools used. We used... -
Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in p...
Abstract Background Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved in nociception and... -
Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-caten...
Abstract Background ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in... -
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in ...
Abstract Background FUS (TLS) and EWS (EWSR1) belong to the FET-protein family of RNA and DNA binding proteins. FUS and EWS are structurally and functionally related and... -
Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD
Abstract Background Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids. A reduced histone deacetylase (HDAC)... -
Galectin-1 from cancer-associated fibroblasts induces epithelial–mesenchymal ...
Abstract Background Gastric cancer (GC) is characterized by the excessive deposition of extracellular matrix, which is thought to contribute to this tumor’s malignant behavior.... -
Plasma levels of increased miR-195-5p correlates with the sFLT-1 levels in pr...
Although the role of soluble fms-like tyrosine kinase 1 (sFLT-1) in preeclampsia is well-established, the mechanism related to its synthesis remains poorly understood. We... -
Macrophage Migration Inhibitory Factor (MIF) Enzymatic Activity and Lung Cancer
Abstract The cytokine macrophage migration inhibitory factor (MIF) possesses unique tautomerase enzymatic activity, which contributes to the biological functional activity of... -
Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transiti...
Abstract Background Multi-walled carbon nanotubes (MWCNT) are currently under intense toxicological investigation due to concern on their potential health effects. Current in... -
Phase I study of samalizumab in chronic lymphocytic leukemia and multiple mye...
Abstract Purpose Samalizumab is a novel recombinant humanized monoclonal antibody that targets CD200, an immunoregulatory cell surface member of the immunoglobulin superfamily... -
Expression of ACE2 and a viral virulence-regulating factor CCN family member ...
Abstract It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS)... -
Aberrant activation of NF-κB signaling in mammary epithelium leads to abnorma...
Abstract Background Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though... -
Major differential gene regulation in Coxiella burnetii between in vivo and i...
Abstract Background Coxiella burnetii is the causative agent of the zoonotic disease Q fever. As it is an intracellular pathogen, infection by C. burnetii requires adaptation to...
