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Associations of tobacco smoking with body mass distribution; a population-bas...
Abstract Background Studies indicate an effect of smoking toward abdominal obesity, but few assess hip and waist circumferences (HC and WC) independently. The present study... -
PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma
Abstract Background The Wnt/β-catenin pathway has a key role in regulating cellular processes and its aberrant signaling can lead... -
Role of goblet cell protein CLCA1 in murine DSS colitis
Abstract Background The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride... -
Untapped potential of multicenter studies: a review of cardiovascular risk pr...
Abstract Background Clinical prediction models are often constructed using multicenter databases. Such a data structure poses additional challenges for statistical analysis... -
The selective peroxisome proliferator-activated receptor alpha modulator (SPP...
Abstract In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the... -
Pharmacological pain relief and fear of childbirth in low risk women; seconda...
Abstract Background Fear of childbirth may reduce the womens’ pain tolerance during labour and may have impact on the mother-infant interaction. We aimed to assess (1) the... -
A combined epigenome- and transcriptome-wide association study of the oral ma...
Abstract Background The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong... -
Systematic mapping of existing tools to appraise methodological strengths and...
Abstract Background Qualitative evidence synthesis is increasingly used alongside reviews of effectiveness to inform guidelines and other decisions. To support this use, the... -
A cluster randomized controlled trial of extending ART refill intervals to si...
Abstract Background The antiretroviral therapy (ART) adherence club (AC) differentiated service delivery model, where clinically stable ART patients receive their ART refills... -
Mercury exposure and risk of cardiovascular disease: a nested case-control st...
Abstract Background Substantial evidence suggests that consuming 1–2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for... -
Typology of birth centres in the Netherlands using the Rainbow model of integ...
Abstract Background The goal of integrated care is to offer a continuum of care that crosses the boundaries of public health, primary, secondary, and tertiary care. Integrated... -
Fetal sex and maternal pregnancy outcomes: a systematic review and meta-analysis
Abstract Background Since the placenta also has a sex, fetal sex–specific differences in the occurrence of placenta-mediated complications could exist. Objective To determine... -
Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid i...
Abstract Background The endogenous secretory receptor for advanced glycation end products (esRAGE) is a soluble isoform produced by alternative splicing of the RAGE gene. The... -
Serum vitamin D levels in Berliners of Turkish descent –a cross-sectional study
Background: Vitamin D levels may differ between migrant and non-migrant populations, especially among non-western immigrants living in a country with limited sun exposure such... -
Newborn Behavioral Observation, maternal stress, depressive symptoms and the ...
Abstract Background Families can experience the postpartum period as overwhelming and many report a special need for support. The Newborn Behavioral Observation (NBO) aims to... -
Subjective and objective assessment of physical activity in multiple sclerosi...
Abstract Background Physical activity (PA) is frequently restricted in people with multiple sclerosis (PwMS) and aiming to enhance PA is considered beneficial in this... -
Clinical effect modifiers of antibiotic treatment in patients with chronic lo...
Abstract Background Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown... -
Point-of-care testing for emergency assessment of coagulation in patients tre...
Abstract Background Point-of-care testing (POCT) of coagulation has been proven to be of great value in accelerating emergency treatment. Specific POCT for direct oral... -
Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomiz...
Abstract Background Our objective was to evaluate the efficacy (clinical and biomarker) and safety of intravenous bapineuzumab in patients with mild to moderate Alzheimer’s... -
The role of hypercapnia in acute respiratory failure
Abstract The biological effects and physiological consequences of hypercapnia are increasingly understood. The literature on hypercapnia is confusing, and at times...
