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Real world experience of patients with amyotrophic lateral sclerosis (ALS) in...
Background: Treatment of spasticity poses a major challenge in amyotrophic lateral sclerosis (ALS) patient management. Delta-9-tetrahydrocannabinol (THC):cannabidiol (CBD)... -
Neuronal impairment following chronic Toxoplasma gondii infection is aggravat...
Abstract Background It has become increasingly evident that the immune and nervous systems are closely intertwined, relying on one another during regular homeostatic conditions.... -
Long-term colonisation with donor bacteriophages following successful faecal ...
Abstract Background Faecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection.... -
Prioritising pathogens for the management of severe febrile patients to impro...
Abstract Background Severe febrile illness without a known source (SFWS) is a challenge for clinicians when deciding how to manage a patient, particularly given the wide... -
Immune responses upon Campylobacter jejuni infection of secondary abiotic mic...
Abstract Background Campylobacter jejuni infections are of rising importance worldwide. Given that innate immune receptors including nucleotide-oligomerization-domain-2 (Nod2)... -
Transient detectable viremia and the risk of viral rebound in patients from t...
Abstract Background Temporary increases in plasma HIV RNA ('blips') are common in HIV patients on combination antiretroviral therapy (cART). Blips above 500 copies/mL have been... -
Self-monitoring of health data by patients with a chronic disease: does disea...
Background: There is a growing emphasis on self-monitoring applications that allow patients to measure their own physical health parameters. A prerequisite for achieving... -
dedup_wf_001--39c2dd95fe4025379e9d8a43a1fbbcaf
Manipulation of the microbiome is an emerging approach to promote health. We conducted a Phase Ia safety study of a single bladder instillation of probiotics in asymptomatic... -
Risk perception of blood transfusions – a comparison of patients and allied h...
Background: Due to an increasing demand in health care services plans to substitute selective physician-conducted medical activities have become attractive. Because... -
Role of goblet cell protein CLCA1 in murine DSS colitis
Abstract Background The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride... -
Toll-like receptor-4 differentially mediates intestinal and extra-intestinal ...
Abstract Background Infections with multi-drug resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa (PA) have become a serious threat particularly in... -
High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population ...
Abstract Background Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest... -
Acute ileitis facilitates infection with multidrug resistant Pseudomonas aeru...
Abstract Background The rising incidence of multidrug resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa has become a serious issue in prevention of its... -
Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in i...
Background: The clinical utility of serum procalcitonin levels in guiding antibiotic treatment decisions in patients with sepsis remains unclear. This patient-level... -
A transcriptomic snapshot of early molecular communication between Pasteuria ...
© The Author(s). 2018 -
Occurrence of marked sepsis-induced immunosuppression in pediatric septic sho...
Abstract Background While the process of sepsis-induced immunosuppression is now well described in adults, very little information is available on immune functions in pediatric... -
The cost of influenza-associated hospitalizations and outpatient visits in Kenya
Background: We estimated the cost-per-episode and the annual economic burden associated with influenza in Kenya. Methods: From July 2013–August 2014, we recruited patients with... -
The role of the intra-abdominal view in complicated intra-abdominal infections
Abstract Background The prognostic role of what a surgeon observes in the abdomen of patients with complicated intra-abdominal... -
Campylobacter jejuni infection of conventionally colonized mice lacking nucle...
Abstract Background The nucleotide-binding oligomerisaton protein 2 (NOD2) constitutes a pivotal sensor of bacterial muramyl dipeptide and assures expression of distinct... -
Potential impact of multiple interventions on HIV incidence in a hyperendemic...
Abstract Background Multiple prevention interventions, including early antiretroviral therapy initiation, may reduce HIV incidence in hyperendemic settings. Our aim was to...
