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Development of an infant feeding core outcome set for childhood obesity inter...
Abstract Background Childhood obesity is a significant public health challenge that affects approximately one in five children worldwide. Infant feeding practices are implicated... -
Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10...
Abstract Background Streptomyces venezuelae ATCC 10712 produces antibiotics chloramphenicol (Cml) and jadomycin (Jad) in response to nutrient limitation and ethanol shock (ES),... -
Two subphenotypes of septic acute kidney injury are associated with different...
Abstract Background The pathophysiology of septic acute kidney injury is inadequately understood. Recently, subphenotypes for... -
Cord blood DNA methylation reflects cord blood C-reactive protein levels but ...
Abstract Background Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory... -
A global sensitivity analysis approach for morphogenesis models
Abstract Background Morphogenesis is a developmental process in which cells organize into shapes and patterns. Complex, non-linear and multi-factorial models with images as... -
Specificity versus redundancy in the RAP2.4 transcription factor family of Ar...
Abstract Background The Arabidopsis ERFIb / RAP2.4 transcription factor family consists of eight members with highly conserved DNA binding domains. Selected members have been... -
An inventory of collaborative medication reviews for older adults - evolution...
Abstract Background Collaborative medication review (CMR) practices for older adults are evolving in many countries. Development has been under way in Finland for over a... -
PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma
Abstract Background The Wnt/β-catenin pathway has a key role in regulating cellular processes and its aberrant signaling can lead... -
Role of goblet cell protein CLCA1 in murine DSS colitis
Abstract Background The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride... -
Untapped potential of multicenter studies: a review of cardiovascular risk pr...
Abstract Background Clinical prediction models are often constructed using multicenter databases. Such a data structure poses additional challenges for statistical analysis... -
Abdominal obesity increases metabolic risk factors in non-obese adults: a Hun...
Abstract Background The prevalence of abdominal obesity is increasing worldwide. Adults with abdominal obesity have been reported to have increased risk of cardiometabolic... -
Pharmacological pain relief and fear of childbirth in low risk women; seconda...
Abstract Background Fear of childbirth may reduce the womens’ pain tolerance during labour and may have impact on the mother-infant interaction. We aimed to assess (1) the... -
A combined epigenome- and transcriptome-wide association study of the oral ma...
Abstract Background The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong... -
Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid i...
Abstract Background The endogenous secretory receptor for advanced glycation end products (esRAGE) is a soluble isoform produced by alternative splicing of the RAGE gene. The... -
Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associat...
Abstract Background Acute kidney injury (AKI) is a multifactorial syndrome, but knowledge about its pathophysiology and possible... -
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability t...
Abstract Background Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here... -
Protocol for a systematic review and meta-analysis of research on the associa...
Abstract Background Existing evidence on the association between exposure to bullying and sleep is limited and inconclusive. The aims of this planned systematic review and... -
Physiologically variable ventilation reduces regional lung inflammation in a ...
Abstract Background Benefits of variable mechanical ventilation based on the physiological breathing pattern have been observed both in healthy and injured lungs. These benefits... -
Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency pro...
Abstract Background Perturbation of commensal intestinal microbiota has been associated with several autoimmune diseases. Mice deficient in interleukin-1 receptor antagonist... -
Microarray expression studies on bone marrow of patients with Shwachman-Diamo...
We report the expression analysis of bone marrow (BM) cells of patients with Shwachman-Diamond syndrome (SDS), in relation to the presence of clonal chromosome anomalies:...
