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Development of a promoter shutoff system in <i>Aspergillus oryzae</i> using a...
Promoter shutoff is a general method for analyzing essential genes, but in the fungus Aspergillus oryzae, no tightly repressed promoters have been reported. To overcome the... -
Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammatio...
Abstract Background The interaction between astrocytes and microglia plays a vital role in the damage and repair of brain lesions due to traumatic brain injury (TBI). Recent... -
Self-directed learning readiness of Indian medical students: a mixed method s...
Abstract Background Self-directed learning (SDL) is defined as learning on oneâ s own initiative, with the learner having primary responsibility for planning, implementing, and... -
Do four or more antenatal care visits increase skilled birth attendant use an...
Abstract Background With Bangladeshâ s adoption of the third Sustainable Development Goal to reduce maternal mortality, the impetus for Bangladesh to continue to improve uptake... -
Dried blood spot versus venous blood sampling for phenylalanine and tyrosine
Abstract Background This study investigated the agreement between various dried blood spot (DBS) and venous blood sample measurements of phenylalanine and tyrosine... -
Prevalence and characteristics of older adults with a persistent death wish w...
Abstract Background Some older persons develop a persistent death wish without being severely ill, often referred to as “completed life” or “tiredness of life”. In the... -
Erythropoietin as an add-on treatment for cognitive side effects of electroco...
Abstract Background Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but its use is impeded by its cognitive side effects. Novel treatments... -
Outcomes in pediatric studies of medium-chain acyl-coA dehydrogenase (MCAD) d...
Abstract Background Inherited metabolic diseases (IMDs) are a group of individually rare single-gene diseases. For many IMDs, there is a paucity of high-quality evidence that... -
Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sc...
Abstract Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are types of major TDP-43 (43-kDa TAR DNA-binding protein) proteinopathy. Cortical... -
The Video intervention to Inspire Treatment Adherence for Life (VITAL Start):...
Abstract Background Improving maternal antiretroviral therapy (ART) retention and adherence is a critical challenge facing prevention of mother-to-child transmission (PMTCT) of... -
Identifying clinical subgroups in IgG4-related disease patients using cluster...
Abstract Background To explore the clinical patterns of patients with IgG4-related disease (IgG4-RD) based on laboratory tests and the number of organs involved. Methods... -
Serum amyloid A primes microglia for ATP-dependent interleukin-1β release
Abstract Background Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A... -
Consumers attitudes and beliefs towards the receipt of antenatal corticostero...
Abstract Background Active participation of consumers in health care decision making, policy and clinical research is increasingly encouraged by governments, influential bodies... -
Pathological complete response due to a prolonged time interval between preop...
Abstract Background Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a... -
UK national clinical audit: management of pregnancies in women with HIV
Abstract Background The potential for HIV transmission between a pregnant woman and her unborn child was first recognized in 1982. Since then a complex package of measures to... -
A multicenter randomized controlled trial of surgery alone or surgery with at...
Abstract Background Postoperative cancer recurrence is a major problem following curative surgery. In a previous retrospective study of lung cancer surgery, we reported that... -
Serum progesterone distribution in normal pregnancies compared to pregnancies...
Abstract Background Progesterone is a critical hormone in early pregnancy. A low level of serum progesterone is associated with threatened miscarriage. We aim to establish the... -
Ca2+ in the dorsal raphe nucleus promotes wakefulness via endogenous sleep-wa...
Abstract Serotonergic neurons in the dorsal raphe nucleus (DRN) are involved in the control of sleep-wake states. Our previous studies have indicated that calcium (Ca2+)... -
Survey on medication information literacy and influencing factors among pregn...
Background: The use of medication during pregnancy is very common. Medication safety has been a great concern among pregnant women and is highly influenced by women’s medication... -
Appendectomy, cholecystectomy and diagnostic laparoscopy conducted before pre...
Abstract Background Non-obstetric surgery conducted during pregnancy may increase the risk of adverse birth outcomes like small for gestational age, preterm birth, and...
