2,513 items found

Types: publication Tags: Genetics Pharmacology

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  • publication

    Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,...

    Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a...
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    Quantitative structure–activity relationship models for compounds with antico...

    Introduction: Third-generation antiepileptic drugs have seemingly failed to improve the global figures of seizure control and can still be regarded as symptomatic treatments....
  • publication

    The analysis of the expenditure behavior of G20 countries

    Introduction: This project is about the expenditure behavior of the 10 of the G20 countries. The G20 (or Group of Twenty) is an international forum for the governments and...
  • publication

    r37980778c78--1432abdeb57253465dd8e782cca54e4b

    A fluorescent deoxyuridine analogue is sensitive to the polarity of its environment and exhibits a distinct emission profile in single- vs double-stranded oligonucleotides....
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    Additional file 1: of Successful contemporary reverse controlled antegrade an...

    Timeline of the Clinical Course. (DOCX 15 kb)
  • publication

    Wind Lidar Digitalization

    Wind lidar technology has been increasingly used for wind energy applications for over a decade. During this time there has been an impressive development of a lidar community...
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    The imprint of X-ray photoevaporation on the orbital distribution of giant pl...

    Recent exoplanet surveys have highlighted the existence of an impressive diversity of planetary systems, raising the question of how systems similar to our own can form and...
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    Additional file 1: of Imbalanced target prediction with pattern discovery on ...

    Supplementary materials of the manuscript. (DOCX 68Â kb)
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    Magnetic Fluorescent Delivery Vehicle Using Uniform Mesoporous Silica Spheres...

    We synthesized uniform pore-sized mesoporous silica spheres embedded with magnetite nanocrystal and quantum dots. The magnetic separation, luminescent detection, and controlled...
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    <i>N</i>-Phenylphenylglycines as Novel Corticotropin Releasing Factor Recepto...

    Screening of a computationally designed synthetic library led to the discovery of the N-phenylphenylglycines (NPPGs) as a novel class of human corticotropin releasing factor...
  • publication

    dedup_wf_001--4edd6b37544e4fc6acb3bb4fce0088b7

    A major bottleneck for the exploitation of data from the Kepler mission for stellar astrophysics and exoplanet research has been the lack of precise radii and evolutionary...
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    Power and Persistent Identifiers

    Persistent identifiers are critical components of modern and evolving data infrastructure. Like much of the mechanics of civilization, PIDs are based on trusted registries. The...
  • publication

    r37980778c78--56fcee8741a21a8729fa2db393bd30b0

    Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The...
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    Additional file 5 of Registration and local production of essential medicines...

    Additional file 5. Interview guide donors/NGOs.
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    Additional file 1: of Effect of 90Sr internal emitter on gene expression in m...

    Manual cell counts for lymphocytes from blood smears. (PDF 89 kb)
  • publication

    Effect of a 17α-(3-Hydroxypropyl)-17β-acetyl Substituent Pattern on the Gluco...

    Replacing the 17α-acetoxy substituent in an antiprogestational 17β-acetyl-11β-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor...
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    dedup_wf_001--0a887f07728626aec5c06741609c93b6

    Summary of details related to batch genotyping for the AKR1C3 rs12529 SNP. Description of data-Details provided as a requirement of the Standard Strengthening the Reporting of...
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    Additional file 4: of SNP genotyping elucidates the genetic diversity of Magn...

    List of synonymies identified among the Magna Graecia germplasm (sample set #1) analyzed by 18â K SNP array. (DOCX 13 kb)
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    MOESM1 of Neural hyperactivity in the amygdala induced by chronic treatment o...

    Additional file 1: Table S1. The effect of analgesic exposure on CSD anxiety behaviors. Table S2. The effect of analgesic exposure on CSD generation. Table S3. Number of...
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    Additional file 4 of A novel PET tracer 18F-deoxy-thiamine: synthesis, metabo...

    Additional file 4: Figure 3B. B: HNMR result of precursor 5.