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Condition-specific promoter activities in Saccharomyces cerevisiae
Abstract Background Saccharomyces cerevisiae is widely studied for production of biofuels and biochemicals. To improve production efficiency under industrially relevant... -
Bone marrow failure may be caused by chromosome anomalies exerting effects on...
Abstract Background The majority of the cases of bone marrow failure syndromes/aplastic anaemias (BMFS/AA) are non-hereditary and considered idiopathic (80â 85%). The... -
New-onset non-infectious pulmonary manifestations among patients with systemi...
Abstract Objective The objective was to estimate the incidence of lung disease among patients with systemic lupus erythematosus (SLE). Methods Using Swedish register data, we... -
Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Perioperative statin therapy in cardiac and non-cardiac surgery: a systematic...
Abstract Background The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association... -
The contribution of culturomics to the repertoire of isolated human bacterial...
Abstract After a decade of research and metagenomic analyses, our knowledge of the human microbiota appears to have reached a plateau despite promising results. In many studies,... -
Plasma matrix metalloproteinases are associated with incident cardiovascular ...
Abstract Background Altered regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to... -
Perioperative surgery- and anaesthesia-related risks of laparoscopic Roux-en-...
Abstract Background Conservative obesity treatment often leads to limited results. Bariatric surgery is highly efficient, but the candidates are at risk of developing... -
Transcriptionally promiscuous "blurry" promoters in Tc1/mariner transposons a...
Abstract Background We have recently described a peculiar feature of the promoters in two Drosophila Tc1-like elements, Bari1 and Bari3. The AT-richness and the presence of weak... -
iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated d...
Abstract Background Previous research indicated that nitric oxide synthase (NOS) is the key molecule for S-nitrosylation of ryanodine receptor 1 (RyR1) in DMD model mice (mdx... -
Selection of reliable reference genes for the normalisation of gene expressio...
Abstract Background Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles... -
Diabetic retinopathy is associated with the presence and burden of subclinica...
Abstract Background Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2... -
Preparing the next generation of genomicists: a laboratory-style course in me...
Abstract The growing gap between the demand for genome sequencing and the supply of trained genomics professionals is creating an acute need to develop more effective genomics... -
Quantitative analysis of a rare disease network’s international contact datab...
Abstract Background Castleman disease (CD) describes a group of rare and poorly understood lymphoproliferative disorders that include unicentric CD (UCD), Human Herpes Virus-8... -
Complex microseismic activity and depth-dependent stress field changes in Wak...
Abstract We examined the spatial relationship between seismicity and upper crustal structure in the Wakayama region, northwestern Kii Peninsula, Japan, by investigating... -
Association between empirically derived dietary patterns with blood lipids, f...
Abstract Background Dietary patterns (DPs) in India are heterogenous. To date, data on association of indigenous DPs in India with risk factors of nutrition-related... -
Distinct core promoter codes drive transcription initiation at key developmen...
Abstract Background Development is largely driven by transitions between transcriptional programs. The initiation of transcription at appropriate sites in the genome is a key... -
Origin, evolution and conservation of the honey bees from La Palma Island (Ca...
Genetic studies have shown a significant hybridization of local populations of Apis mellifera in the Canary Islands, as a consequence of queen importation. Since La Palma Island... -
Risk factors of renal dysfunction and their interaction in level-low lead exp...
Abstract Background To explore the effect of low-level lead exposure on renal dysfunction in paint works, and analyze the interaction between low-level lead exposure and other... -
MiR-1-3p that correlates with left ventricular function of HCM can serve as a...
Abstract Background MicroRNAs (miRNAs) are non-coding RNAs that function as regulators of gene expression and thereby contribute to the complex disease phenotypes. Hypertrophic...
