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MRI of trunk muscles and motor and respiratory function in patients with myot...
Abstract Background Myotonic Dystrophy 1 (DM1) causes progressive myopathy of extremity muscles. DM1 may also affect muscles of the trunk. The aim of this study was to... -
Development of a promoter shutoff system in <i>Aspergillus oryzae</i> using a...
Promoter shutoff is a general method for analyzing essential genes, but in the fungus Aspergillus oryzae, no tightly repressed promoters have been reported. To overcome the... -
Golgi tethering factor golgin-97 suppresses breast cancer cell invasiveness b...
Abstract Background Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the... -
Prevalence and characteristics of older adults with a persistent death wish w...
Abstract Background Some older persons develop a persistent death wish without being severely ill, often referred to as “completed life” or “tiredness of life”. In the... -
Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their pro...
Abstract Background Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or... -
Involvement of ABC-transporters and acyltransferase 1 in intracellular choles...
Abstract Background Understanding pathogenic mechanisms is imperative for developing novel treatment to the tuberculosis, an important public health burden worldwide. Recent... -
Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sc...
Abstract Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are types of major TDP-43 (43-kDa TAR DNA-binding protein) proteinopathy. Cortical... -
Genome-wide DNA methylation at birth in relation to in utero arsenic exposure...
Abstract Background In utero arsenic exposure may alter fetal developmental programming by altering DNA methylation, which may result in a higher risk of disease in later life.... -
Comparative transcriptomic analyses of normal and malformed flowers in sugar ...
Abstract Background Sugar apple (Annona squamosa L.), a popular fruit with high medicinal and nutritional properties, is widely cultivated in tropical South Asia and America.... -
Pleural effusion from intrathoracic migration of a ventriculo-peritoneal shun...
Abstract Background Pleural effusion is a rare complication of ventriculo-peritoneal (VP) cerebrospinal fluid (CSF) shunting and its diagnosis is difficult in patients with... -
Effects of very early start of norepinephrine in patients with septic shock: ...
Abstract Background Optimal timing for the start of vasopressors (VP) in septic shock has not been widely studied since it is assumed that fluids must be administered in... -
Autonomic nervous system response to remote ischemic conditioning: heart rate...
Abstract Background Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart.... -
Helios + Regulatory T cell frequencies are correlated with control of viral r...
Abstract Background The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation.... -
Patternable particle microarray utilizing controllable particle delivery
Abstract In this study, we demonstrate an on-demand delivering and sequential arraying of single microparticles utilizing multiple pneumatic pressure-driven elastomer valves and... -
Excessive carbohydrate consumption and body mass index: the risk factors for ...
Abstract Background Prader-Willi syndrome (PWS) is commonly associated with severe obesity and type 2 diabetes mellitus (T2DM) and is caused by excessive eating. Only very few... -
CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cl...
Abstract Background The CRISPR/dCas9 system is a powerful tool to activate the transcription of target genes in eukaryotic or prokaryotic cells, but lacks assays in complex... -
Correlates of knee bone marrow lesions in younger adults
Abstract Background Subchondral bone marrow lesions (BMLs) play a key role in the pathogenesis of osteoarthritis (OA) and are associated with pain and structural progression in... -
Body image in patients with somatoform disorder
Abstract Background Although body-related problems are common in patients with somatoform disorder, research focusing on how patients with somatoform disorder perceive and... -
HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by...
Abstract Background Hematological and neurological expressed 1 (HN1) is upregulated in many tumors, but the role of HN1 in breast cancer progression and its regulatory mechanism... -
Cherenkov luminescence imaging is a fast and relevant preclinical tool to ass...
Abstract Purpose Molecular imaging techniques visualise biomarkers for both drug development and personalised medicine. In this field, Cherenkov luminescence imaging (CLI) seems...
