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Distinct binding and signaling activity of Acthar Gel compared to other melan...
To compare the binding and agonistic activity of Acthar® Gel and synthetic melanocortin receptor (MCR) agonists and examine how the activity of select agonists affects the in... -
SUMO conjugation regulates immune signalling
Post-translational modifications (PTMs) are critical drivers and attenuators for proteins that regulate immune signalling cascades in host defence. In this review, we explore... -
Cost per responder analysis of guselkumab versus targeted therapies in the tr...
BACKGROUND The fully human monoclonal antibody guselkumab is an effective treatment option for patients with moderate to severe psoriasis. OBJECTIVE The objective of this study... -
Association of tenofovir disoproxil fumarate exposure with chronic kidney dis...
Tenofovir disoproxil fumarate (TDF)-based regimens have been associated with impaired kidney function and loss of bone mineral density among patients living with HIV (PLWH). We... -
dedup_wf_001--8b69457db6e992d656d964dd667f136d
Mesenchymal stem cell transplantation (MSCT) has been applied to treat a variety of autoimmune and inflammatory diseases. Psychosocial stress can aggravate disease progression... -
Expression of ADR-α1, 2 and ADR-β2 in cumulus cell culture of infertile women...
Alpha and beta-adrenoceptors (ADR-α1, 2, and β2) play a regulatory role in the folliculogenesis and steroidogenesis in the ovarian follicles. This study aimed to measure these... -
Does subnational tax autonomy promote regional convergence? Evidence from OEC...
This paper investigates the simultaneous impact of subnational tax autonomy and vertical transfers on regional disparities of gross domestic product (GDP) per head in a sample... -
A multi-level weighted transformation based neuro-fuzzy domain adaptation tec...
In this manuscript, a neuro-fuzzy domain adaptation (DA) technique has been proposed for a multi-level incremental transformation of the source-target features to find an... -
Clinical characteristics in young-adult ALS – results from a Portuguese cohor...
Studies concerning young-adult amyotrophic lateral sclerosis (yALS) are uncommon, due to the rarity of this condition. We aimed to investigate this subject. Methods: A... -
From pigments to coloured napkins: comparative analyses of primary aromatic a...
A collaborative study was conducted to understand the correlation between pigments purity profile (primary aromatic amine content of the pigments) and the behaviour of these... -
Unveiling the diversity of spatial data infrastructures in Latin America: evi...
Geospatial information has transformed into a primary consumer good in our society. Worldwide, governmental organizations have contributed to this reality through Spatial Data... -
My emotions belong here and there: extending the phenomenon of emotional accu...
When immigrant minorities engage in a new cultural context, their patterns of emotional experience come to change – a process we coined emotional acculturation. To date,... -
RNA secondary structure at the transcription start site influences EBOV trans...
Ebola virus (EBOV) RNA has the potential to form hairpin structures at the transcription start sequence (TSS) and reinitiation sites of internal genes, both on the genomic and... -
dedup_wf_001--a66673170c588b96a033e52307ed883a
Lavandula angustifolia Mill. (lavender) and Origanum heracleoticum L. (greek oregano) are aromatic plants used in traditional medicine for relief of convulsion, anxiety,... -
Out of Africa: novel source of small hive beetles infesting Eastern and Weste...
Small hive beetles (SHB, Aethina tumida Murray, Coleoptera: Nitidulidae) are parasites of social bee colonies endemic to sub-Saharan Africa and have become an invasive species.... -
‘No taxation without hypothecation’: towards an improved understanding of the...
Although it is widely acknowledged that taxation is a powerful instrument for combating environmental problems, environmental taxation is still underused. Public acceptability... -
Long-read sequencing uncovers a complex transcriptome topology in varicella z...
Abstract Background Varicella zoster virus (VZV) is a human pathogenic alphaherpesvirus harboring a relatively large DNA molecule. The VZV transcriptome has already been...
