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An Eigenvalue test for spatial principal component analysis
AbstractBackgroundThe spatial Principal Component Analysis (sPCA, Jombart 2008) is designed to investigate non-random spatial distributions of genetic variation. Unfortunately,... -
MetaDiff: differential isoform expression analysis using random-effects meta-...
Background RNA sequencing (RNA-Seq) allows an unbiased survey of the entire transcriptome in a high-throughput manner. A major application of RNA-Seq is to detect differential... -
Handling missing rows in multi-omics data integration: multiple imputation in...
Background In omics data integration studies, it is common, for a variety of reasons, for some individuals to not be present in all data tables. Missing row values are... -
QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-...
Background Gene expression connectivity mapping has proven to be a powerful and flexible tool for research. Its application has been shown in a broad range of research topics,... -
Addressing inaccuracies in BLOSUM computation improves homology search perfor...
Background BLOSUM matrices belong to the most commonly used substitution matrix series for protein homology search and sequence alignments since their publication in 1992. In... -
"MRMPlus: an open source quality control and assessment tool for SRM/MRM assa...
Background Selected and multiple reaction monitoring involves monitoring a multiplexed assay of proteotypic peptides and associated transitions in mass spectrometry runs. To...
