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Size and Shape Selectivity of Host Networks Built Based on Tunable Secondary ...
By modulating the secondary building units derived from the primary building units, N-acylsalicylhydrazides (H3xshz), we have been able to construct isostructural but tunable... -
r37980778c78--3cbb85f240e8f79621aaa13e4858bfa7
Novel deoxycholic acid-based cyclic receptors, 3 and 4, containing two imidazolium groups and m-xylene and p-xylene as spacers have been synthesized. These receptors bind anions... -
Novel Bile Acid-Based Cyclic Bisimidazolium Receptors for Anion Recognition
Novel deoxycholic acid-based cyclic receptors, 3 and 4, containing two imidazolium groups and m-xylene and p-xylene as spacers have been synthesized. These receptors bind anions... -
Shape-Selective Separation of Molecular Isomers with Tunable Hydrogen-Bonded ...
The propensity of hydrogen-bonded guanidinium (G) organodisulfonates (S) to form crystalline inclusion compounds has been investigated in the context of separating isomeric... -
r37980778c78--99cfe978489eb1ee16cb22675701096d
A two-step, three-component coupling of an alkyne, enol ether, and vinyl diazoester was accomplished by use of successive metal carbene-catalyzed transformations. This efficient... -
1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines: A Series of Potent and...
The discovery of new highly potent and selective dopamine D3 receptor antagonists has recently permitted characterization of the role of the dopamine D3 receptor in a wide range... -
Bowl-Shaped <i>C</i><sub>3</sub>-Symmetric Receptor with Concave Phosphine Ox...
A bowl-shaped C3-symmetric receptor (1a) that has a phophine oxide functionality in the interior of a “molecular bowl” shows remarkable selectivity for Asn derivatives. -
r37980778c78--363f5870e3102e9701adc3fd44959431
For the first time, we show that chlorine has a dramatic effect on the selectivity for olefin epoxidation promoted by Au. Chlorine coadsorbed with oxygen on Au(111) inhibits... -
Synthesis and Structure−Activity Relationship of Fluoro Analogues of 8-{2-[4-...
We have discovered high-affinity antagonists (exemplified by 11 and 12) that are the most selective for α1d-adrenergic receptors (α1d-AR) reported to date. In cloned receptor... -
Rational Design of Cavitand Receptors for Mass Sensors
This Communication describes a rational approach to the fabrication of selective mass sensors, using multiple hydrogen-bonding type interactions encoded in a single cavitand... -
r37980778c78--4a75748113cec1dc6789505afcaa3491
6-Methyl-1-oxa-4-thiaspiro[4.5]dec-6-ene-7-carbaldehyde was treated with a variety of nucleophiles under varying conditions. Whereas the 1,4-diastereoselectivity observed with... -
Philicity: A Unified Treatment of Chemical Reactivity and Selectivity
A generalized concept of philicity is introduced through a resolution of identity, encompassing electrophilic, nucleophilic, and radial reactions. Locally, a particular... -
Discovery of a Novel Series of Biphenyl Benzoic Acid Derivatives as Potent an...
A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human β3 adrenergic receptor (β3-AR)... -
r37980778c78--92750c3e51a0fe81dff57fc7a40bd0eb
A new fluorescent molecular sensor for Hg2+ based on the phosphane sulfide derivative exhibits a very low detection limit in an aqueous medium (3.8 nM) with a very high... -
Breaking the <i>C</i><sub>3</sub>-Symmetry of Chiral Tripodal Oxazolines: En...
A phenylglycinol-derived tripodal oxazoline with C1-symmetry (C1-PhBTO) was synthesized, and its enantioselective recognition behavior toward α-chiral primary organoammonium... -
r37980778c78--3884631482b90688f24b37b0d3d8f546
The effect on potency and selectivity of modifications at the C6 position of the cardioprotective KATP opener BMS-180448 (2) is described. Structure−activity studies show that a... -
A Novel Thiourea-Based Dual Fluorescent Anion Receptor with a Rigid Hydrazine...
A neutral receptor with a rigid hydrazine spacer, N-p-(dimethylamino)benzamido-N‘-phenylthiourea, was prepared, and its dual fluorescence in acetonitrile was found to show... -
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Stru...
A set of quinolone-3-carboxamides 2 bearing diverse substituents at position 1, 3, and 6 of the bicyclic nucleus was prepared. Except for six compounds exhibiting Ki > 100... -
r37980778c78--075141e6c8b2a236fc060ef3bba67458
Synthesis and metal binding properties of thiolariat ethers, where a sulfide side chain is introduced into a framework of a crown ether, have been performed. Remarkably high Ag+... -
Metal Carbene-Promoted Sequential Transformations for the Enantioselective Sy...
A two-step, three-component coupling of an alkyne, enol ether, and vinyl diazoester was accomplished by use of successive metal carbene-catalyzed transformations. This efficient...
