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Design and Synthesis of a Novel Series of <i>N</i>-Alkyl Isatin Acylhydrazone...
There is growing interest in using cannabinoid receptor 2 (CB2) agonists for the treatment of neuropathic pain. We have synthesized a novel series of N-alkyl isatin... -
r37980778c78--0dbe15ed22d31ec802dfc5d921aebf3b
The identification of aromatic steroid hydrocarbons bearing a methyl group at positions 1, 2, 3, 4, or 6 in sediments and petroleum has been puzzling since possible steroidal... -
r37980778c78--1e2aa22680152f2e243a37786e6f85bb
The identification of aromatic steroid hydrocarbons bearing a methyl group at positions 1, 2, 3, 4, or 6 in sediments and petroleum has been puzzling since possible steroidal... -
r37980778c78--dc669ea7dab313dcdfbab5d71f789ca6
The polyfluorination of α-(arylthio)carbonyl compounds was achieved by a successive application of polyfluorination using IF5, Friedel−Crafts arylation, and desulfurizing... -
r37980778c78--e676242d05173b064a936129fc9143ec
The synthesis and structure−activity relationship of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 (TRPV1) antagonists are described. A variety of... -
Systematic Analysis of Public Domain Compound Potency Data Identifies Selecti...
Molecular scaffolds that yield target family-selective compounds are of high interest in pharmaceutical research. There continues to be considerable debate in the field as to... -
Synthesis of Optically Active Vicinal Fluorohydrins by Lipase-Catalyzed Derac...
Three microbial lipases have been used to deracemize trans-2-fluorocycloalkanols 2 both by hydrolysis of the corresponding acetates 3 or chloroacetates 4 and by esterification... -
In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent a...
α1 Adrenergic receptors mediate both vascular and lower urinary tract tone, and α1 receptor antagonists such as terazosin (1b) are used to treat both hypertension and benign... -
Phase Equilibria in Ionic Liquid−Aromatic Compound Mixtures, Including Benzen...
This work extends the scope of previous studies on the phase behavior of mixtures of ionic liquids with benzenes or its derivatives by determining the solid−liquid and... -
Two-Step Metal-Mediated Transformation of Isoxazolidine-5-spirocyclopropanes ...
The two-step metal-catalyzed overall transformation of isoxazolidine-5-spirocyclopropanes into the corresponding dihydro- and tetrahydropyridones is described. The first step is... -
r37980778c78--7f0d4d109bd26b011f364ee8348c2574
The mixtures of toxins and taste-and-odor compounds present during cyanobacterial blooms are not well characterized and of particular concern when evaluating potential human... -
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Stru...
A set of quinolone-3-carboxamides 2 bearing diverse substituents at position 1, 3, and 6 of the bicyclic nucleus was prepared. Except for six compounds exhibiting Ki > 100... -
Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative...
The synthesis and biological activity of tetrahydronaphthalene derivatives coupled to various heterocycles are described. These compounds are potent glucocorticoid receptor... -
r37980778c78--062004a8e344636f311ce6479b8097a8
We describe the primary aerobic biodegradation of an unleaded, unoxygenated, regular gasoline by inocula from unacclimated fresh and sea water, and from a domestic sewage... -
r37980778c78--ea2566fbf2ca5468abd1da0decc3fd0a
A concise total synthesis of (S)-14-methoxyepothilone D has been accomplished. (S)-14-Methoxyepothilone D represents a conceptually novel example of polyketide analogue design... -
Probes for Narcotic Receptor Mediated Phenomena. 23. Synthesis, Opioid Recept...
The highly selective delta (δ) opioid receptor agonist SNC 80 [(+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, (+)-21] and... -
First Regioselective Ortho-Lithiation Induced by a 2-Chloropyridyl Group Comp...
It is shown that t-BuLi in Et2O promotes an exclusive regioselective metalation of 2-aryl-6-chloropyridine compounds at the aromatic ortho position demonstrating that the... -
r37980778c78--c8f0b9c8a7e7ae2204763b566f787c87
The hydrogen-bond-acceptor properties of the carbonyl moiety in the 17β-acetyl group on the D-ring of the anesthetic steroids (3α,5α)- and (3α,5β)-3-hydroxypregan-20-one form an... -
r37980778c78--d0ebe2814062ecb3ce9ee0005febddbd
The design of a range of 4-position-modified d-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along... -
r37980778c78--411741071553152d157982d5ba0e3677
Normal state conductivity and superconductivity together with bulk magnetic susceptibility and magnetization measurements have been measured for two molecular charge-transfer...
