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The COMET Handbook: Version 1.0
Abstract The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to... -
A review of reviews on principles, strategies, outcomes and impacts of resear...
Abstract Background Conducting research in partnership with stakeholders (e.g. policy-makers, practitioners, organisations, patients) is a promising and popular approach to... -
Systematic review of clinical practice guidelines recommendations about prima...
Abstract Background Clinical care for older adults is complex and represents a growing problem. They are a diverse patient group with varying needs, frequent presence of... -
Use of theory to plan or evaluate guideline implementation among physicians: ...
Abstract Background Guidelines support health care decision-making and high quality care and outcomes. However, their implementation is sub-optimal. Theory-informed, tailored... -
Rational and design of an individual participant data meta-analysis of spinal...
Abstract Background Chronic low back pain (LBP) is the leading cause of pain and disability, resulting in a major socioeconomic impact. The Cochrane Review which examined the... -
Risk factors for necrotizing enterocolitis in neonates: a systematic review o...
Abstract Background Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into... -
The influence of pregnancy on the pharmacokinetic properties of artemisinin c...
Abstract Background Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based... -
Performance of critical care prognostic scoring systems in low and middle-inc...
Abstract Background Prognostic modelsâ used in critical care medicine for mortality predictions, for benchmarking and for illness stratification in clinical trialsâ have been... -
Socio-cultural determinants of physical activity across the life course: A 'D...
Abstract Objective Regular physical activity (PA) reduces the risk of disease and premature death. Knowing factors associated with PA might help reducing the disease and... -
Assessing the effect of interventions for axial spondyloarthritis according t...
Abstract The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record...
