528 items found

Tags: Biophysics Computational Biology Pharmacology

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  • dataset

    dedup_wf_001--cff1dac5252e02e12bfd323f52db5ec6

    Additional file 1: Figure S1. Dynamics of inflammatory mechanims across DCI beyond 48 hours. A cluster including VEGF, FGF2, IL12p70, IL17A and IFNg, and separate small cluster...
  • dataset

    Visualization 2: Focusing light with orbital angular momentum by circular arr...

    Electric field distribution of the vortex beam measured in time-domain. Originally published in Optics Express on 12 June 2017 (oe-25-12-13728)
  • dataset

    Additional file 3: of Alternative DNA secondary structure formation affects R...

    A list of 5959 pausing sites located outside of RefSeq gene bodies. (DAT 234 kb)
  • dataset

    Deprotonation and Addition Reactions of Frustrated Lewis Pairs with Alkynes

    Deprotonation of terminal alkynes is effected by the treatment with tBu3P and B(C6F5)3 to give [tBu3PH][PhCCB(C6F5)3] (1a) and [tBu3PH][RCCB(C6F5)3] (R = nBu 2, tBu 3, Me3Si 4,...
  • dataset

    Activation of <i>PPARγ2</i> by PPARγ1 through a functional PPRE in transdiffe...

    PPARγ and Wnt signaling are central positive and negative regulators of adipogenesis, respectively. Here we identified that, eicosapentaenoic acid (EPA) could effectively induce...
  • dataset

    Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of g...

    Abstract Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases,...
  • dataset

    Emerging MET tyrosine kinase inhibitors for the treatment of non-small cell l...

    aberrations, including MET exon 14 skipping mutation and amplification, are present in ~5% of non-small cell lung cancer (NSCLC) cases, and these levels are comparable to the...
  • dataset

    Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer

    Abstract Background CpG islands (CGIs) are interspersed DNA sequences that have unusually high CpG ratios and GC contents. CGIs are typically located in the promoter of...
  • dataset

    Applications of Bis(1-R-imidazol-2-yl)disulfides and Diselenides as Ligands f...

    Bis(1-R-imidazol-2-yl)disulfides, (mimR)2 (R = Ph, But), and diselenides, (seimMes)2, serve as bidentate N,N-donor ligands for main-group and transition metals. For example,...
  • dataset

    Effect of dose and dose rate on temporal γ-H2AX kinetics in mouse blood and s...

    Abstract Background Cesium-137 (137Cs) is one of the major and most clinically relevant radionuclides of concern in a radiological dispersal device, “dirty bomb” scenario as...
  • dataset

    Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen...

    Abstract Background Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and...
  • dataset

    Review and Analysis of FDA Approved Drugs using Lipid-based Formulations

    Lipid-based drug delivery systems (LBDDS) are one of the most studied bioavailability enhancement technologies and are utilized in a number of FDA approved drugs. While...
  • dataset

    Additional file 4 of Retinoic acid receptor-related orphan receptor α reduces...

    Additional file 4. Supplementary figure of immunoblot analysis (Fig. 7d). THP1 cells were treated with 100 nM phorbol 12-myristate 13-acetate (PMA) for 72 h and then treated...
  • dataset

    Additional file 2: of A validated single-cell-based strategy to identify diag...

    A spreadsheet file containing all the data cited in the text in several sheets (ordered by appearance). Description: Description of the content in each sheet in the document....
  • dataset

    Scaling approach in predicting the seatbelt loading and kinematics of vulnera...

    Objective: Occupants with extreme body size and shape, such as the small female or the obese, were reported to sustain high risk of injury in motor vehicle crashes (MVCs)....
  • dataset

    Longer analgesic effect with naproxen sodium than ibuprofen in post-surgical ...

    Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as first-line medications in mild-to-moderate acute pain. However, comparative data regarding the...
  • dataset

    Synthesis, Structure, and Isomerization of Decapentynylcorannulene:  Enediyne...

    Decapentynylcorannulene (5) is prepared via aryl−alkyne coupling chemistry of decachlorocorannulene and trimethylstannylpentyne. The crystal structure of 5 is compared with the...
  • dataset

    ZENO1

    I'll do this after I wake-up, not meaning that I'm not awake, only that I shouldn't be. Clearly.
  • dataset

    Guest Inclusion and Structural Dynamics in 2-D Hydrogen-Bonded Metal−Organic ...

    Guest Inclusion and Structural Dynamics in 2-D Hydrogen-Bonded Metal−Organic Frameworks
  • dataset

    dedup_wf_001--f67f327051279b9cfa0c567880986120

    Open Science logo (.tif) Builds on Open Source logo by David Gerard (http://commons.wikimedia.org/wiki/User:David_Gerard) from...