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Cost Analysis of Integrating the PrePex Medical Device into a Voluntary Medic...
Background Fourteen African countries are scaling up voluntary medical male circumcision (VMMC) for HIV prevention. Several devices that might offer alternatives to the three... -
dedup_wf_001--87621acd46c5aab91ef3cbb037f951a7
Background Growing evidence suggests that second-generation cryoballoon ablation (2G-CB) is effective in patients with persistent atrial fibrillation (PerAF). The cornerstone... -
Conflicts of interest in GM Bt crop efficacy and durability studies
Public confidence in genetically modified (GM) crop studies is tenuous at best in many countries, including those of the European Union in particular. A lack of information... -
Pharmacologic control of oxidative stress and inflammation determines whether...
Diabetic kidney disease (DKD) is characterized by progressive glomerulosclerosis (GS). ROP mice have a sclerosis-prone phenotype. However, they develop severe, rapidly... -
How long do new medicines take to reach Canadian patients after companies fil...
Introduction Studies of the delay between when companies file a New Drug Submission (NDS) and when drugs reach Canadian patients typically focus on the time in the regulatory... -
Pharmacological characterization of potent and selective NaV1.7 inhibitors en...
Identification of voltage-gated sodium channel NaV1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent... -
Sevoflurane Inhalation Accelerates the Long-Term Memory Consolidation via Sma...
Sevoflurane exposure impairs the long-term memory in neonates. Whether the exposure to animals in adolescence affects the memory, however, has been unclear. A small hydrolase... -
dedup_wf_001--09dde878d97e3be4c5a214418ffcbaca
ABSTRACTThe pathogenesis of spinal cord injury (SCI) remains poorly understood and treatment remains limited. Emerging evidence indicates the severity of post-SCI inflammation... -
A typology of community and stakeholder engagement based on documented exampl...
Background Despite broad consensus on the importance of community and stakeholder engagement (CSE) for guiding the development, regulation, field testing, and deployment of... -
Gatekeepers or Intermediaries? The Role of Clinicians in Commercial Genomic T...
Background Many commentators on “direct-to-consumer” genetic risk information have raised concerns that giving results to individuals with insufficient knowledge and training... -
Wolbachia enhances West Nile virus (WNV) infection in the mosquito Culex tars...
Novel strategies are required to control mosquitoes and the pathogens they transmit. One attractive approach involves maternally inherited endosymbiotic Wolbachia bacteria.... -
Systematic review and meta-analysis comparing Adjustable Transobturator Male ...
BACKGROUND AND PURPOSE: Urinary incontinence is one of the most serious complications of prostate cancer treatment. The objective of this study was to assess efficacy and safety... -
Ten simple rules for helping newcomers become contributors to open projects.
To survive and thrive, a community must attract new members, retain them, and help them be productive [1]. As openness becomes the norm in research, software development, and... -
Retention and promotion of women and underrepresented minority faculty in sci...
The current climate on college campuses has brought new urgency to the need to increase faculty diversity. In STEM fields particularly, the dearth of underrepresented minority... -
In vitro transcribed guide RNAs trigger an innate immune response via the RIG...
Fast-moving, competitive fields often inadvertently duplicate research. In a research environment that values being first over being robust, this results in one manuscript... -
Haves and have nots must find a better way: The case for open scientific hard...
With the current rapid spread of COVID-19, global health systems are increasingly overburdened by the sheer number of people that need diagnosis, isolation and treatment.... -
How do research faculty in the biosciences evaluate paper authorship criteria?
Authorship on peer-reviewed journal articles and abstracts has become the main currency and reward unit in academia. Such a reward has become a crucial component for students... -
Provenance and risk in transfer of biological materials
Whereas biological materials were once transferred freely, there has been a marked shift in the formalisation of exchanges involving these materials, primarily through the use...
