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On the Stereospecific Conversion of Proximally-Oxygenated Trisubstituted Viny...
Allylically oxygenated vinyl α-triphenylstannanes such as 22 can be readily converted into vinyl iodides and thereafter stereodefined trisubstituted alkenes with retention of... -
Construction of Novel Polycyclic Ring Systems by Transition-Metal-Catalyzed C...
Construction of Novel Polycyclic Ring Systems by Transition-Metal-Catalyzed Cycloisomerization of Ene−Ene−Ynes. Interception of a Carbenoid Intermediate in Skeletal... -
Sagittamides A and B. Polyacetoxy Long-Chain Acyl Amino Acids from a Didemnid...
An unidentified tunicate from Pohnpei, Micronesia, yielded sagittamides A and Bcompounds comprising a long-chain C26 dicarboxylic acid that acylates terminal l-valine and... -
A Theoretical Study of the Chorismate Synthase Reaction
: Density functional calculations (B3LYP/6-31+G(d,p)) were carried out to investigate the mechanism of the anti-1,4-elimination of phosphate from... -
Engineering the enolase magnesium II binding site: implications for its evolu...
The glycolytic enzyme enolase catalyzes the reversible elimination of water from 2-phosphoglycerate (2-PGA) to form phosphoenolpyruvate (PEP). Two magnesium ions in the active... -
Modulation of T2 Relaxation Time by Light-Induced, Reversible Aggregation of ...
A reversible T2 contrast agent consisting of cross-linked anionic dextran coated iron oxide nanoparticles covalently coupled to a light-sensitive spiropyran (SP)/merocyanine... -
Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamani...
Coibamide A (1) is a new, potent antiproliferative depsipeptide which was isolated from a marine Leptolyngbya cyanobacterium collected from the Coiba National Park, Panama. The... -
Covalent Organic Frameworks as Exceptional Hydrogen Storage Materials
We report the H_2 uptake properties of six covalent organic frameworks (COFs) from first-principles-based grand canonical Monte-Carlo simulations. The predicted H_2 adsorption... -
Local Current Mapping and Patterning of Reduced Graphene Oxide
Conductive atomic force microscopy (C-AFM) has been used to correlate the detailed structural and electrical characteristics of graphene derived from graphene oxide. Uniform... -
Au@ZIF-8: CO Oxidation over Gold Nanoparticles Deposited to Metal−Organic Fra...
Gold nanoparticles (NPs) were deposited to a zeolite-type metal−organic framework (MOF) by a simple solid grinding method. A catalyst, Au@ZIF-8, represents the first example of... -
Tris(2,6-diphenylbenzyl)silyl Group as a New and Highly Effective Protector f...
Tris(2,6-diphenylbenzyl)silyl Group as a New and Highly Effective Protector for Carboxylic Acids: Unusual Behavior of Such Carboxylic Esters toward Common Nucleophiles and Bases -
Charge Migration in Dicationic Electrophiles and Its Application to the Synth...
Superacid-promoted reactions of dicationic electrophiles have been studied, and the positive charge centers are found to migrate apart in a predictable manner. Using isotopic... -
An Experimental and Theoretical Study of a Bicyclic Acetal Equilibrium
The position of equilibrium for competitive acetal formation can be hard to predict. This example, the core of zaragozic acid, is finely balanced, but an experimental... -
Synthesis of Tetrasubstituted Ethylenes on Solid Support via Resin Capture
Synthesis of Tetrasubstituted Ethylenes on Solid Support via Resin Capture -
Total Synthesis of the Anticancer Natural Product OSW-1
The highly potent anticancer natural saponin OSW-1 has been successfully synthesized from commercially available 5-androsten-3β-ol-17-one 79 in 10 operations with 28% overall... -
A Triple Diene-Transmissive Diels−Alder Strategy To Build the Quassinoid Fram...
An advanced intermediate to the highly oxygenated triterpene quassinoids was prepared in 14 steps from tetrahydrofuran. The key steps are three diene-transmissive Diels−Alder... -
Synthesis and Magnetic Investigation of Ordered Mesoporous Two-Line Ferrihydrite
We report here for the first time on the synthesis and characterization of ordered mesoporous two-line ferrihydrite. Ordered mesoporous ferrihydrite has been prepared via the... -
"Clickable" Metal−Organic Framework
We demonstrated the metal−organic framework bearing the azide group in the organic linkers and in situ click reactions with some small alkynes. The XRPD patterns indicated that... -
Synthesis of the Azaspiracid-1 Trioxadispiroketal
The de novo analysis, design, and synthesis of the azaspiracid-1 trioxadispiroketal system is described. A revised structural model was developed on the basis of an independent... -
Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Ort...
The reactivity of a series of symmetrical chiral Bronsted acids (polar ionic hydrogen-bond donors) follows the counterintuitive trend wherein the more Bronsted basic member is a...
