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Altering pyrroloquinoline quinone nutritional status modulates mitochondrial,...
We have reported that pyrroloquinoline quinone (PQQ) improves reproduction, neonatal development, and mitochondrial function in animals by mechanisms that involve mitochondrial... -
What parents of children who have received emergency care think about deferri...
OBJECTIVE: To investigate parents' views about deferred consent to inform management of trial disclosure after a child's death. METHODS: A postal questionnaire survey was... -
Secure Surveillance of Antimicrobial Resistant Organism Colonization or Infec...
Background There is stigma attached to the identification of residents carrying antimicrobial resistant organisms (ARO) in long term care homes, yet there is a need to collect... -
Willingness to Participate in HIV Vaccine Trials among Men Who Have Sex with ...
Background Recruitment of low- and middle-income country volunteers from most-at-risk populations in HIV vaccine trials is essential to vaccine development. In India, men who... -
Animal Welfare in Studies on Murine Tuberculosis: Assessing Progress over a 1...
There is growing concern over the welfare of animals used in research, in particular when these animals develop pathology. The present study aims to identify the main sources of... -
Lessons from agriculture for the sustainable management of malaria vectors.
The effectiveness of insecticide-treated bed nets and indoor insecticide sprays to control adult mosquito vectors is being threatened by the spread of insecticide resistance. We... -
The Complete Genome Sequence of Mycoplasma bovis Strain Hubei-1
Infection by Mycoplasma bovis (M. bovis) can induce diseases, such as pneumonia and otitis media in young calves and mastitis and arthritis in older animals. Here, we report the... -
Ethical alternatives to experiments with novel potential pandemic pathogens.
Please see later in the article for the Editors' Summary -
Indigenous Health and Socioeconomic Status in India
In 1999, Leon Eisenberg wrote an essay entitled, “Does social medicine still matter in an era of molecular medicine?” [1]. Anticipating the scientific discussion that would... -
Open Clinical Trial Data for All? A View from Regulators
Peter Doshi and colleagues describe their experience trying and failing to access clinical study reports from the manufacturer of Tamiflu and challenge industry to defend their... -
Role of Nrf2/ARE Pathway in Protective Effect of Electroacupuncture against E...
NF-E2 related factor 2 (Nrf2) is a major transcription factor and acts as a key regulator of antioxidant genes to exogenous stimulations. The aim of current study was to... -
Comparison of Closed-Ended, Open-Ended, and Perceived Informed Consent Compre...
Verifying participant comprehension continues to be a difficult ethical and regulatory challenge for clinical research. An increasing number of articles assessing methods to... -
Improving Ethical and Participatory Practice for Marginalized Populations in ...
BACKGROUND:This paper presents findings from a qualitative investigation of ethical and participatory issues related to the conduct of biomedical HIV prevention trials among... -
Impact of stakeholders influence, geographic level and risk perception on str...
Comparison of control strategies against animal infectious diseases allows determining optimal strategies according to their epidemiological and/or economic impacts. However, in... -
Do Xpert MTB/RIF Cycle Threshold Values Provide Information about Patient Del...
INTRODUCTION: Early diagnosis and initiation to appropriate treatment is vital for tuberculosis (TB) control. The XpertMTB/RIF (Xpert) assay... -
Improving Access to Medicines in Poor Countries: The Role of Universities
According to the World Health Organization, about 10 million people—most of them in low- and middle-income countries—die needlessly every year because they do not have access to... -
Justice Is the Missing Link in One Health: Results of a Mixed Methods Study i...
Background One Health (OH) is an interdisciplinary collaborative approach to human and animal health that aims to break down conventional research and policy ‘silos’. OH has... -
Global Elimination of Lymphatic Filariasis: A "Mass Uprising of Compassion"
Hospitals and medical centers often cite compassion as a core value in their mission statements. In contrast, the importance of compassion in global health is rarely... -
A regulatory structure for working with genetically modified mosquitoes: less...
Policy Platform A Regulatory Structure for Working with Genetically Modified Mosquitoes: Lessons from Mexico Janine M. Ramsey 1 , J. Guillermo Bond 1 , Maria Elena Macotela 1 ,... -
A modified experimental hut design for studying responses of disease-transmit...
Differences between individual human houses can confound results of studies aimed at evaluating indoor vector control interventions such as insecticide treated nets (ITNs) and...
