122 items found

Tags: Article Pharmacology

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  • publication

    Optimising daytime deliveries when inducing labour using prostaglandin vagina...

    © 2015 The Author(s). Published by Taylor & Francis. Objective: To determine induction start time(s) that would maximise daytime deliveries when using prostaglandin...
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    Neural substrates of subphonemic variation and lexical competition in spoken ...

    In spoken word recognition, subphonemic variation influences lexical activation, with sounds near a category boundary increasing phonetic competition as well as lexical...
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    Homochiral Crystallization of Microporous Framework Materials from Achiral Pr...

    While it is not uncommon to form chiral crystals during crystallization, the formation of bulk porous homochiral materials from achiral building units is rare. Reported here is...
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    A Pyrrolyl-Based Triazolophane: A Macrocyclic Receptor With CH and NH Donor G...

    A pyrrolyl-based triazolophane, incorporating CH and NH donor groups, acts as a receptor for the pyrophosphate anion in chloroform solution. It shows selectivity for this...
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    How U.S. research institutions are responding to the single Institutional Rev...

    One of the most significant changes to the Common Rule is the requirement that institutions use a single Institutional Review Board (IRB) for cooperative research in the United...
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    Clouds and "throat hit": Effects of liquid composition on nicotine emissions ...

    Electronic cigarettes (ECIGs) heat and vaporize a liquid mixture to produce an inhalable aerosol that can deliver nicotine to the user. The liquid mixture is typically composed...
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    Optimal design of perturbations for individual two-compartment pharmacokineti...

    We consider the optimal design of pharmacokinetic studies in patients that receive intermittent hemodialysis and intravenous antibiotic. Hemodialysis perturbs the...
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    Comparative cardiopulmonary toxicity of exhausts from soy-based biofuels and ...

    Increased use of renewable energy sources raise concerns about health effects of new emissions. We analyzed relative cardiopulmonary health effects of exhausts from (1) 100% soy...
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    On high-dimensional constrained maximum likelihood inference*

    Inference in a high-dimensional situation may involve regularization of a certain form to treat overparameterization, imposing challenges to inference. The common practice of...
  • publication

    Associations between driving under the influence or riding with an impaired d...

    Objective: Risky driving behaviors among adolescents, such as riding with a drinking or impaired driver (RWID) or driving while under the influence (DUI) of alcohol or drugs,...
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    Dihydroxyacetone Levels in Electronic Cigarettes: Wick Temperature and Toxin ...

    Recently, we reported the presence of dihydroxyacetone (DHA), the active ingredient in sunless tanners, in the aerosol of an electronic cigarette. DHA has been shown to react...
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    A Bayesian Sequential Design for Clinical Trials With Time-to-Event Outcomes

    There is increasing interest in Bayesian group sequential design because of its potential to improve efficiency in clinical trials, to shorten drug development time, and to...
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    Photoregulated release of caged anticancer drugs from gold nanoparticles

    An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as...
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    Do morphemes matter when reading compound words with transposed letters? Evid...

    The current study investigates the online processing consequences of encountering compound words with transposed letters (TLs), to determine if TLs that cross morpheme...
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    Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement o...

    Inhibitors of heat-induced heat shock protein 70 (HSP70) expression have the potential to enhance the therapeutic effectiveness of heat-induced radiosensitization of tumors....
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    Partial Retro−Inverso, Retro, and Inverso Modifications of Hydrazide Linked B...

    Partially modified retro−inverso, retro, and inverso isomers of hydrazide linked bifunctional peptides were designed, synthesized, and evaluated for bioactivities at δ/μ opioid...
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    Enhanced Diastereoselectivity in β-Mannopyranosylation through the Use of Ste...

    2-O-Propargyl ethers are shown to be advantageous in the 4,6-O-benzylidene acetal directed β-mannosylation reaction. The effect is most pronounced when the O3 protecting group...
  • publication

    dedup_wf_001--937daa650cd0205a6af0bb29ae0bcf11

    Background: This study was conducted to evaluate the safety and tolerability, and population pharmacokinetics (PPK) of montelukast as well as efficacy in the treatment of...
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    A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibit...

    7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. Our preliminary structural−activity relationship (SAR) study showed...
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    Characterization of Recombinant Lysyl Oxidase Propeptide

    Lysyl oxidase enzyme activity is critical for the biosynthesis of mature and functional collagens and elastin. In addition, lysyl oxidase has tumor suppressor activity that has...