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Genotype-phenotype correlations of adult-onset PLA2G6-associated Neurodegener...
Abstract Background Phospholipase A2 group VI (PLA2G6) mutations associated with neurodegeneration (PLAN) manifest as heterogeneous neurodegenerative disorders with variable... -
Food 4 Health - He Oranga Kai: Assessing the efficacy, acceptability and econ...
Abstract Background The rates of pre-diabetes and type 2 diabetes mellitus are increasing worldwide, producing significant burdens for individuals, families, and healthcare... -
A recommender system to quit smoking with mobile motivational messages: study...
Abstract Background Smoking cessation is the most common preventative for an array of diseases, including lung cancer and chronic obstructive pulmonary disease. Although there... -
Helios + Regulatory T cell frequencies are correlated with control of viral r...
Abstract Background The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation.... -
Prevention of cervical cancer in HIV-seropositive women from developing count...
Abstract Background There is scanty or inconclusive evidence on which cervical cancer screening tool is effective and suitable for human immunodeficiency virus... -
Patternable particle microarray utilizing controllable particle delivery
Abstract In this study, we demonstrate an on-demand delivering and sequential arraying of single microparticles utilizing multiple pneumatic pressure-driven elastomer valves and... -
Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
The urgency of utilizing COVID-19 biospecimens for research in the heart of t...
Abstract The outbreak of the novel coronavirus disease 2019 (COVID-19) and consequent social distancing practices have disrupted essential clinical research functions worldwide.... -
Effectiveness of repellent delivered through village health volunteers on mal...
Abstract Background To combat emerging drug resistance in the Greater Mekong Sub-region (GMS) the World Health Organization and GMS countries have committed to eliminating... -
Impact of antibiotic therapy on the development and response to treatment of ...
Abstract Background The gut microbiome impacts the efficacy of immune checkpoint inhibitor (ICI) therapy and the development of ICI-mediated diarrhea and/or colitis (IMDC).... -
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels...
Abstract Background There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of... -
Next-generation sequencing analysis of receptor-type tyrosine kinase genes in...
Abstract Background Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to... -
Comparison of anti-malarial drugs efficacy in the treatment of uncomplicated ...
Abstract Background Artemisinin-based combination therapy (ACT) and novel drug combinations are available and used in African countries to treat uncomplicated malaria. Network... -
Genetic boundaries delineate the potential human pathogen Salmonella bongori ...
Abstract Background Salmonella bongori infect mainly cold-blooded hosts, but infections by S. bongori in warm-blooded hosts have been reported. We hypothesized that S. bongori... -
HIV-1 integrase resistance associated mutations and the use of dolutegravir i...
Abstract Background Sub-Saharan Africa carries the greatest burden of HIV-infection with increasing drug resistance burden, which requires improved patient management and... -
Health-related quality of life in thrombocytopenic patients with chronic hepa...
Abstract Background Despite changes in the treatment paradigm towards non-interferon-based therapies, interferon-based treatments are still used in some geographical regions for... -
Perceived causes and risk factors of Buruli ulcer among patients at Agogo Pre...
Abstract Objective The incidence of Buruli ulcer has been recorded in about 30 countries globally and Africa seems to be the most affected area. The study sought to determine... -
Prevalence of feco-oral transmitted protozoan infections and associated facto...
Abstract Background An estimated 60% of the world’s population is infected with one form of intestinal parasites. Amoebiasis and giardiasis are among the leading intestinal... -
Early morning urine collection to improve urinary lateral flow LAM assay sens...
Abstract Background Urine LAM testing has been approved by the WHO for use in hospitalised patients with advanced immunosuppression. However, sensitivity remains suboptimal. We... -
The magnitude of antibiotic resistance to Helicobacter pylori in Africa and i...
Abstract Background Worldwide Helicobacter pylori (H.pylori) treatment is of great challenge due to increased antibiotic resistance. The burden of H. pylori antibiotic...
