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Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of g...
Abstract Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases,... -
Additional file 1 of DDX5 potentiates HIV-1 transcription as a co-factor of Tat
Additional file 1. Figure S1. Cell viability. (A and B) Cells were seeded in a 96 well at 4 × 103 cells per well and sequentially transfected with 10 pmol of siControl or... -
A functional connectome: regulation of Wnt/TCF-dependent transcription by pai...
Abstract Background Wnt/β-catenin signaling is often portrayed as a simple pathway that is initiated by Wnt ligand at the cell surface leading, via linear series of interactions... -
Transcriptional activation of USP16 gene expression by NFκB signaling
Abstract Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely... -
Heterologous and endogenous U6 snRNA promoters enable CRISPR/Cas9 mediated ge...
Abstract Background U6 promoters have been used for single guide RNA (sgRNA) transcription in the clustered regularly interspaced short palindromic repeats/CRISPR-associated... -
Dimerized translationally controlled tumor protein increases interleukin-8 ex...
Abstract Background Histamine releasing factor (HRF) is a unique cytokine known to regulate a variety of immune cells in late allergic reactions. In the previous study, we... -
Short-term time-restricted feeding during the resting phase is sufficient to ...
Feeding at unusual times of the day is thought to be associated with obesity and metabolic disorders in both experimental animals and humans. We previously reported that... -
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in ...
Background FUS (TLS) and EWS (EWSR1) belong to the FET-protein family of RNA and DNA binding proteins. FUS and EWS are structurally and functionally related and participate in... -
ZENO1
I'll do this after I wake-up, not meaning that I'm not awake, only that I shouldn't be. Clearly. -
dedup_wf_001--f67f327051279b9cfa0c567880986120
Open Science logo (.tif) Builds on Open Source logo by David Gerard (http://commons.wikimedia.org/wiki/User:David_Gerard) from... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
MOESM1 of Transfection of Sertoli cells with androgen receptor alters gene ex...
Addtional file 1: Table S1. Contains raw data (Cq values of reference and target genes) of quantitative RT-PCR analysis. -
HIV induces expression of complement component C3 in astrocytes by NF-κB-depe...
Abstract Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive... -
Architecture of divergent flagellar promoters controlled by CtrA in Rhodobact...
Abstract Background Rhodobacter sphaeroides has two sets of flagellar genes, fla1 and fla2, that are responsible for the synthesis of two different flagellar structures. The... -
"Hit-and-Run" transcription: de novo transcription initiated by a transient b...
Abstract Background Dynamic transcriptional regulation is critical for an organism’s response to environmental signals and yet remains elusive to capture. Such transcriptional... -
Characteristics of the study population.
SD = standard deviation; BMI = body mass index; BFP = Body fat percentage measured with bioelectrical impedance [24]; WHR = waist-hip ratio; HGS = handgrip strength, the highest... -
Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caen...
Abstract Background Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin... -
A CLCA regulatory protein present in the chemosensory cilia of olfactory sens...
Abstract Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an... -
Precise annotation of human, chimpanzee, rhesus macaque and mouse mitochondri...
In the present study, we applied our ‘precise annotation’ to the mitochondrial (mt) genomes of human, chimpanzee, rhesus macaque and mouse using 5′ and 3′ end small RNAs. Our... -
Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fati...
Abstract Background The NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3) is an intracellular protein complex that plays an important role in innate...
