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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,...
Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a... -
Additional file 1: of Successful contemporary reverse controlled antegrade an...
Timeline of the Clinical Course. (DOCX 15 kb) -
The imprint of X-ray photoevaporation on the orbital distribution of giant pl...
Recent exoplanet surveys have highlighted the existence of an impressive diversity of planetary systems, raising the question of how systems similar to our own can form and... -
Development of a Novel Self-Microemulsifying Drug Delivery System for Reducin...
The development of HIV protease inhibitors (PIs) has been one of the most significant advances of the past decade in controlling HIV infection. Unfortunately, the benefits of... -
<i>N</i>-Phenylphenylglycines as Novel Corticotropin Releasing Factor Recepto...
Screening of a computationally designed synthetic library led to the discovery of the N-phenylphenylglycines (NPPGs) as a novel class of human corticotropin releasing factor... -
dedup_wf_001--4edd6b37544e4fc6acb3bb4fce0088b7
A major bottleneck for the exploitation of data from the Kepler mission for stellar astrophysics and exoplanet research has been the lack of precise radii and evolutionary... -
dedup_wf_001--35b60e6bc5862c95f994b770eae5e556
Table S1. The cervical microbiota in the LEEP group and the Reference group in women aged <46 years. Table S2. The cervical microbiota six months post treatment in the LEEP... -
dedup_wf_001--0b290ab8163c03c1b59153b3ad16da48
Additional file 7: Figure S5. The morphological characteristics of the stems of d2014 and WT. -
r37980778c78--56fcee8741a21a8729fa2db393bd30b0
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The... -
Additional file 1: of Effect of 90Sr internal emitter on gene expression in m...
Manual cell counts for lymphocytes from blood smears. (PDF 89 kb) -
r37980778c78--5021c87261f3e825dde9a93ad9814f8e
To develop a novel antipsychotic agent which is an agonist of dopamine (DA) autoreceptors and an antagonist of postsynaptic DA receptors, a series of 7-[4-[4-(substituted... -
r37980778c78--20d5cb9ef2131f7c2f5fd1f5ab7c3f3a
The development of n-pentenyl furanosyl donors has been tested using arabinose as a model. The readily prepared ortho ester (NPOE) is converted into disarmed (NPGAC) and thence... -
Pulmonary toxicity of synthetic amorphous silica – effects of porosity and co...
Materials can be modified for improved functionality. Our aim was to test whether pulmonary toxicity of silica nanomaterials is increased by the introduction of: a) porosity;... -
Effect of a 17α-(3-Hydroxypropyl)-17β-acetyl Substituent Pattern on the Gluco...
Replacing the 17α-acetoxy substituent in an antiprogestational 17β-acetyl-11β-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor... -
Additional file 5: of Acceptability of healthcare interventions: an overview ...
When was acceptability assessed?. Description of data: Summary of the timing of acceptability assessments relative to start of intervention reported in the papers identified in... -
MOESM1 of Neural hyperactivity in the amygdala induced by chronic treatment o...
Additional file 1: Table S1. The effect of analgesic exposure on CSD anxiety behaviors. Table S2. The effect of analgesic exposure on CSD generation. Table S3. Number of... -
Additional file 4 of A novel PET tracer 18F-deoxy-thiamine: synthesis, metabo...
Additional file 4: Figure 3B. B: HNMR result of precursor 5. -
r37980778c78--e669c313d8a9cdc92fd1159467d7eb1e
The derivatives of ethylenediamine-N,N,N‘,N‘-tetraamides were prepared, and their crystal structures were analyzed in order to understand the variations in their molecular and... -
Additional file 2: Figure S1. of Aberrant KDM5B expression promotes aggressiv...
Relative expression of KDM5B, MALAT1, SNAIL, Vimentin and miR 448 normalized against GAPDH in MCF10A WT, MCF10A OE, MDA-MB-231 WT and MDA-MB-231 KD cells. Data are... -
Design and Synthesis of 5‘-Deoxy-5‘-Phenyladenophostin A, a Highly Potent IP<...
5‘-Deoxy-5‘-phenyladenophostin A (5), designed as a useful IP3 receptor ligand based on the previous structure−activity relationship studies, was successfully synthesized via...
