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Regioselective Carboindation of Simple Alkenes with Indium Tribromide and Ket...
The regioselective carboindation of simple alkenes with indium tribromide and ketene silyl acetals was accomplished. Various alkenes such as ethylene, 1-alkenes, and cyclic... -
Effect of a 17α-(3-Hydroxypropyl)-17β-acetyl Substituent Pattern on the Gluco...
Replacing the 17α-acetoxy substituent in an antiprogestational 17β-acetyl-11β-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor... -
Lewis Acid-Promoted Conjugate Addition of Dienol Silyl Ethers to Nitroalkenes...
A novel γ-selective conjugate addition of 1-silyl-substituted dienol ethers to nitroalkenes activated by Lewis acids has been developed. The resulting α,β-unsaturated... -
Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and A...
Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and Antiviral Agents -
Novel oxidative aromatic alkene cleavage with sodium nitrite under mild condi...
We have developed a simple and practical process for the oxidation of aromatic alkene to the corresponding carbonyl compounds using NaNO2 as an oxidant. The practical utility of... -
Oxidative Aromatization of 9,10-Dihydroanthracenes Using Molecular Oxygen Pro...
Substituted 9,10-dihydroanthracenes were oxidatively aromatized to the corresponding anthracenes effectively by using molecular oxygen as an oxidant and activated carbon (Darco... -
Systems pharmacology approach to investigate the molecular mechanisms of herb...
Rhodiola rosea L. radix (RRL) is one of the most popular medical herb which has been widely used for the treatment of different diseases effectively, including cardiovascular... -
Synthetic Study of Selective Benzylic Oxidation
Oxidation of bisbenzyl ethers was studied using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ). Compared to other benzylic oxidations such as Kornblum type reaction of benzyl... -
Unusual Transannular Cyclization Products of Sarcophytoxide, a 14-Membered Ma...
Treatment of sarcophytoxide with trimethylsilyl trifluoromethanesulfonate afforded an aromatic ketone as an unusual cyclization product. The modified Mosher's method and X-ray... -
Preparation and unequivocal identification of the regioisomers of nitrocatech...
ABSTRACTThe four positional isomers of nitrocatechol monobenzyl ether were prepared as intermediates to nitrobenzodioxanes directly from 2-benzyloxyphenol or, through two-four... -
Reactions of α,α‘-Dihydroxy Ketones with Phosgene. Structural Requirements fo...
α,α‘-Dihydroxy ketones having two OH groups that can come into close proximity react with phosgene in the presence of DMAP to produce 1,3-dioxane-2,5-diones. When covalent... -
A New Method for the Synthesis of Branched Polysilane Anions
Lithiation by MeLi of three families of branched polysilanes (Me3Si)3Si−X {(1) X = SiMe2H, t-BuMe2Si, SiMe2SiMe3, t-BuSiMe2SiMe2; (2) X = SiMe(SiMe3)2, Si(SiMe3)3,... -
Intramolecular Carbolithiation Reactions for the Preparation of Azabicyclo[2....
Tin−lithium exchange and intramolecular carbolithiation (anionic cyclization) have been used to construct the three nitrogen-positional isomers of the azabicyclo[2.2.1]heptane... -
Antimalarial Activity of a New Family of Analogues of Manzamine A
Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies. The synthesis and biological evaluation of a group of simplified... -
Stereoselective Rhodium-Catalyzed Imination of Sulfides.
International audience; The preparation of optically active sulfilimines via the catalytic diastereoselective imination of sulfides using a chiral nitrene is described.... -
dedup_wf_001--062354a1a3ec4caaf097a0cdeb8bc738
Due to the interest in the biological properties of marine derived α-galactoglycosphingolipids (α-GalGSLs), a lot of work has focused on the development of their synthesis. Here... -
Enantioselective Epoxidation of Terminal Olefins by Chiral Dioxirane
This paper describes an enantioselective epoxidation of terminal olefins using chiral ketone 3 as catalyst and Oxone as oxidant. Up to 85% ee has been obtained. -
Profilin 2 promotes migration, invasion, and stemness of HT29 human colorecta...
We investigated the role of profilin 2 in the stemness, migration, and invasion of HT29 cancer stem cells (CSCs). Increased and decreased levels of profilin 2 significantly... -
Josiphos-Catalyzed Asymmetric Homodimerization of Ketoketenes
In this paper the development of a chiral phosphine-catalyzed homodimerization of ketoketenes that provides access to a variety of highly substituted ketoketene dimer β-lactones... -
Application of Stereoselective Ether Transfer to the Synthesis of Isotactic P...
An efficient, convergent synthetic strategy has been developed which enables the synthesis of a series of naturally occurring isotactic polymethoxy compounds. Ether transfer...
