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Effect of a 17α-(3-Hydroxypropyl)-17β-acetyl Substituent Pattern on the Gluco...
Replacing the 17α-acetoxy substituent in an antiprogestational 17β-acetyl-11β-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor... -
On the Stereospecific Conversion of Proximally-Oxygenated Trisubstituted Viny...
Allylically oxygenated vinyl α-triphenylstannanes such as 22 can be readily converted into vinyl iodides and thereafter stereodefined trisubstituted alkenes with retention of... -
Lewis Acid-Promoted Conjugate Addition of Dienol Silyl Ethers to Nitroalkenes...
A novel γ-selective conjugate addition of 1-silyl-substituted dienol ethers to nitroalkenes activated by Lewis acids has been developed. The resulting α,β-unsaturated... -
Asymmetric Synthesis of Enantioenriched (+)-Elaeokanine A
The key transformation in the total synthesis of (+)-elaeokanine A was accomplished by asymmetric deprotonation of N-Boc pyrrolidine, followed by the reaction of the in situ... -
Novel oxidative aromatic alkene cleavage with sodium nitrite under mild condi...
We have developed a simple and practical process for the oxidation of aromatic alkene to the corresponding carbonyl compounds using NaNO2 as an oxidant. The practical utility of... -
Identification of a Boron-Containing Intermediate in the Boron Tribromide Med...
An alternate reaction mechanism for the boron tribromide mediated deprotection of aryl propargyl ethers based on the isolation of a key boron-containing byproduct is proposed.... -
Oxidative Aromatization of 9,10-Dihydroanthracenes Using Molecular Oxygen Pro...
Substituted 9,10-dihydroanthracenes were oxidatively aromatized to the corresponding anthracenes effectively by using molecular oxygen as an oxidant and activated carbon (Darco... -
Commercialization and Late-Stage Development of a Semisynthetic Antifungal AP...
Many years ago anidulafungin 1 was identified as a potentially useful medicine for the treatment of fungal infections. Its chemical and physical properties as a relatively high... -
Electrochemical oxidative iodination of imidazo[1,2-a]pyridines using NaI as ...
An electrochemical oxidative iodination of imidazo[1,2-a]pyridines is achieved in this study. This reaction utilizes NaI as an iodine source and a supporting electrolyte under... -
Systems pharmacology approach to investigate the molecular mechanisms of herb...
Rhodiola rosea L. radix (RRL) is one of the most popular medical herb which has been widely used for the treatment of different diseases effectively, including cardiovascular... -
Synthesis of Optically Active 5-Alkoxy-6-methylcyclohex-2-en-1-ones and 4-Alk...
The reaction of (−)-(1E,3Z)-2-methyl-1-((1S)-1-phenylethoxy)penta-1,3-dien-3-ol benzoate with allyltrimethylsilane in SO2 and in the presence of a catalytic amount of Tf2NTMS... -
Unusual Transannular Cyclization Products of Sarcophytoxide, a 14-Membered Ma...
Treatment of sarcophytoxide with trimethylsilyl trifluoromethanesulfonate afforded an aromatic ketone as an unusual cyclization product. The modified Mosher's method and X-ray... -
Preparation and unequivocal identification of the regioisomers of nitrocatech...
ABSTRACTThe four positional isomers of nitrocatechol monobenzyl ether were prepared as intermediates to nitrobenzodioxanes directly from 2-benzyloxyphenol or, through two-four... -
Reactions of α,α‘-Dihydroxy Ketones with Phosgene. Structural Requirements fo...
α,α‘-Dihydroxy ketones having two OH groups that can come into close proximity react with phosgene in the presence of DMAP to produce 1,3-dioxane-2,5-diones. When covalent... -
Effect of 2,6-Disubstituted Aryl Groups on Acyclic Conformation: Preference ...
Multiple X-ray crystallographic and 1H NMR spectroscopic studies demonstrate that 2,6-disubstituted aryl groups exert a strong effect on acyclic conformation, inducing the... -
A New Method for the Synthesis of Branched Polysilane Anions
Lithiation by MeLi of three families of branched polysilanes (Me3Si)3Si−X {(1) X = SiMe2H, t-BuMe2Si, SiMe2SiMe3, t-BuSiMe2SiMe2; (2) X = SiMe(SiMe3)2, Si(SiMe3)3,... -
Intramolecular Carbolithiation Reactions for the Preparation of Azabicyclo[2....
Tin−lithium exchange and intramolecular carbolithiation (anionic cyclization) have been used to construct the three nitrogen-positional isomers of the azabicyclo[2.2.1]heptane... -
Antimalarial Activity of a New Family of Analogues of Manzamine A
Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies. The synthesis and biological evaluation of a group of simplified... -
Cycloadditions of Aromatic Azomethine Imines with 1,1-Cyclopropane Diesters
The cycloaddition of aromatic azomethine imines to 1,1-cyclopropane diesters was achieved using Ni(ClO4)2 as catalyst. The methodology gives access to unique tricyclic... -
Stereoselective Rhodium-Catalyzed Imination of Sulfides.
International audience; The preparation of optically active sulfilimines via the catalytic diastereoselective imination of sulfides using a chiral nitrene is described....
