-
Conflict of Interest Disclosures for Clinical Practice Guidelines in the Nati...
Background Conflict of interest (COI) is an important potential source of bias in the development of clinical practice guidelines (CPGs) and high rates of COI among guideline... -
The need for randomization in animal trials: an overview of systematic reviews
Background and Objectives: Randomization, allocation concealment, and blind outcome assessment have been shown to reduce bias in human studies. Authors from the Collaborative... -
How Industry Uses the ICMJE Guidelines to Manipulate Authorship--And How They...
Ghostwriting and guest authorship of medical journal articles raise serious ethical and legal concerns, bearing on the integrity of medical research and evidence used in legal... -
Sample Size Requirements for Studies of Treatment Effects on Beta-Cell Functi...
Preservation of -cell function as measured by stimulated C-peptide has recently been accepted as a therapeutic target for subjects with newly diagnosed type 1 diabetes. In... -
What parents of children who have received emergency care think about deferri...
OBJECTIVE: To investigate parents' views about deferred consent to inform management of trial disclosure after a child's death. METHODS: A postal questionnaire survey was... -
Outcome Reporting Bias in Government-Sponsored Policy Evaluations: A Qualitat...
The reporting of evaluation outcomes can be a point of contention between evaluators and policy-makers when a given reform fails to fulfil its promises. Whereas evaluators are... -
Assessing the efficacy and safety of fecal microbiota transplantation and pro...
Background Fecal microbiota transplantation is an effective treatment for many gastrointestinal diseases, such as Clostridium difficile infection and inflammatory bowel... -
Workflow in Clinical Trial Sites & Its Association with Near Miss Events for ...
BACKGROUND: With the exponential expansion of clinical trials conducted in (Brazil, Russia, India, and China) and VISTA (Vietnam, Indonesia, South Africa, Turkey, and Argentina)... -
Development of a knowledge translation platform for ataxia: Impact on readers...
AbstractBackgroundDissemination of accurate health research information to patients and families has become increasingly important with the rise of the internet as a means of... -
The Efficacy of Chinese Herbal Medicine as an Adjunctive Therapy for Advanced...
Many published studies reflect the growing application of complementary and alternative medicine, particularly Chinese herbal medicine (CHM) use in combination with conventional... -
Applying the risk of bias tool in a systematic review of combination long-act...
Background The Risk of Bias (RoB) tool is used to assess internal validity of randomized controlled trials (RCTs). Our objectives were to: 1) evaluate inter-rater agreement of... -
Trial registration numbers are underreported in biomedical publications.
CONTEXT: Since September 2005, the International Committee of Medical Journal Editors (ICMJE) has required that randomised controlled trials (RCTs) are prospectively registered... -
Willingness to Participate in HIV Vaccine Trials among Men Who Have Sex with ...
Background Recruitment of low- and middle-income country volunteers from most-at-risk populations in HIV vaccine trials is essential to vaccine development. In India, men who... -
Improving the trustworthiness, usefulness, and ethics of biomedical research ...
The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists,... -
How could artificial intelligence aid in the fight against coronavirus?
Background News coverage of medical research is followed closely by many Americans and affects the practice of medicine and influence of scientific research. Prior work has... -
Participant Informed Consent in Cluster Randomized Trials: Review
BACKGROUND: The Nuremberg code defines the general ethical framework of medical research with participant consent as its cornerstone. In cluster randomized trials (CRT),... -
Agreements between Industry and Academia on Publication Rights: A Retrospecti...
Background Little is known about publication agreements between industry and academic investigators in trial protocols and the consistency of these agreements with corresponding... -
Conflict of Interest Policies for Organizations Producing a Large Number of C...
Background Conflict of interest (COI) of clinical practice guideline (CPG) sponsors and authors is an important potential source of bias in CPG development. The objectives of... -
Informed Consent: How Much Awareness Is There?
© 2014 Purcaru et al. Improving the informed consent process in clinical research is of constant concern to regulatory authorities in the field and presents a challenge for both... -
Accelerometry Measuring the Outcome of Robot-Supported Upper Limb Training in...
Purpose This study aims to assess the extent to which accelerometers can be used to determine the effect of robot-supported task-oriented arm-hand training, relative to...
