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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,...
Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a... -
dedup_wf_001--6a72594ea900de3929241813a2954b20
Lightning talk presented at Collaborations Workshop 2019 organised by the Software Sustainability Institute. -
Telling the Whole Tale via Reproducible Data Reuse
Whole Tale provides a platform for reproducible research in which researchers can access data from archival repositories, mix that with locally uploaded data, and build and run... -
Coffee Lecture: Planning and Structuring. Storage of Research Data, Hildeshei...
This Coffee Lecture explained how to organise data and why during one's research. Research data are the backbone of research. Processing, maintenance, structured storage and... -
<i>N</i>-Phenylphenylglycines as Novel Corticotropin Releasing Factor Recepto...
Screening of a computationally designed synthetic library led to the discovery of the N-phenylphenylglycines (NPPGs) as a novel class of human corticotropin releasing factor... -
Catalytic Carbon−Halogen Bond Activation: Trends in Reactivity, Selectivity,...
We have theoretically studied the oxidative addition of all halomethanes CH3X (with X = F, Cl, Br, I, At) to Pd and PdCl-, using both nonrelativistic and... -
r37980778c78--56fcee8741a21a8729fa2db393bd30b0
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The... -
r37980778c78--93183a566ab17aaa0191dac4b12dd679
A Streptavidin−Protein Cage Janus Particle for Polarized Targeting and Modular Functionalization -
Aryl Bridged 1-Hydroxypyridin-2-one: Effect of the Bridge on the Eu(III) Sens...
The efficiency of Eu3+ luminescence by energy transfer from an antenna ligand can be strongly dependent on the metal ion coordination geometry. The geometric component of the... -
A Logic Modelling Workflow For Systems Pharmacology
Modern biology has made great advances in our knowledge of the workings of organisms at the molecular level. Although there is still much to be learned in this area, many... -
System boundary selection in life-cycle inventories using hybrid approaches
Life-cycle assessment (LCA) is a method for evaluating the environmental impacts of products holistically, including direct and supply chain impacts. The current LCA... -
Access Control
Publisher Summary Access control is the control of access to property, services, events, or information, and is a combination of several things including control, record... -
Miniaturized Planar Chromatography Using Office Peripherals
High-performance thin-layer chromatography is a separation technique commonly used to identify and quantify components in chemical mixtures. Sophisticated analytical tools are... -
Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and A...
Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and Antiviral Agents -
r37980778c78--fe4e83e064bdf00dc834ea490c40288c
A ratiometric fluorescent biosensor for Hg2+ is constructed from the MerR protein and a duplex DNA containing a pyrene excimer. -
r37980778c78--6aa789157cd7338db059b4619ee64ff7
A Path Sampling Study of Ru-Hydride-Catalyzed H2 Hydrogenation of Ethylene -
Solve for X(ML): Transforming metadata to transform data access
At the University of Alberta, a subscription to data resources from the Linguistic Data Consortium (LDC) presented a cataloguing problem for library staff and access... -
Nitration of the tumor suppressor protein, p53, at tyrosine 327 promotes p53 ...
Previous studies demonstrate that nitric oxide (NO) promotes p53 transcriptional activity by a classical DNA damage responsive mechanism involving activation of ATM/ATR and... -
Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (...
A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and... -
Harnessing the power of supercomputers using the PanDA Pilot 2 in the ATLAS E...
The unprecedented computing resource needs of the ATLAS experiment have motivated the Collaboration to become a leader in exploiting High Performance Computers (HPCs). To meet...
