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r37980778c78--088172a2a7cda9b5bc4673bb862e5a4a
From the roots of Lespedeza cyrtobotrya, 45 flavonoids were isolated along with 20 new and 25 known compounds. Lipophilic flavonoids 2, 3, 7, 9, 11, 28, 30, and 39 exhibited... -
Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,...
Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a... -
Development of a Novel Self-Microemulsifying Drug Delivery System for Reducin...
The development of HIV protease inhibitors (PIs) has been one of the most significant advances of the past decade in controlling HIV infection. Unfortunately, the benefits of... -
Catalytic Carbon−Halogen Bond Activation: Trends in Reactivity, Selectivity,...
We have theoretically studied the oxidative addition of all halomethanes CH3X (with X = F, Cl, Br, I, At) to Pd and PdCl-, using both nonrelativistic and... -
r37980778c78--f5680ee4bfad1708193c9c95ea6978c9
Ultrafast 2D HMBC spectroscopy permits real-time monitoring of a reaction based on the structural changes produced in a carbonyl carbon atom. This new technique was used to... -
r37980778c78--20d5cb9ef2131f7c2f5fd1f5ab7c3f3a
The development of n-pentenyl furanosyl donors has been tested using arabinose as a model. The readily prepared ortho ester (NPOE) is converted into disarmed (NPGAC) and thence... -
r37980778c78--308e0d829603d8f8f45ed47c2eb7a3bc
Exposure to diesel exhaust (DE) has been associated with acute cardiopulmonary and vascular responses, chronic noncancer health effects, and respiratory cancers in humans. To... -
Ruthenium-Catalyzed [2 + 2] Cycloadditions of Bicyclic Alkenes with Alkynyl P...
Ruthenium-catalyzed [2 + 2] cycloadditions of bicyclic alkenes with alkynyl phosphonates were investigated. The phosphonate moieties were found to be compatible with the... -
Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (...
A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and... -
Design and Synthesis of Potent Cystine-Free Cyclic Hexapeptide Agonists at th...
Cyclic hexapeptides, incorporating a dipeptide unit in place of the disulfide bond found in urotensin, were prepared and screened at the human urotensin receptor. The bridging... -
1,1-Dichloroethene as a Predominant Intermediate of Microbial Trichloroethene...
A microbial culture derived from a landfill site in Dover, DE consistently reduced trichloroethene (TCE) to ethene through 1,1-dichloroethene (DCE) as a dominant intermediate in... -
r37980778c78--894f5a0f2f7e00094737f83bfc26b423
CAN is a good reagent for the transformation of 2-hydroxyethyl ether units to alcohols. Significantly, many functional groups can tolerate the reaction conditions, although they... -
Anhydrolide Macrolides. 1. Synthesis and Antibacterial Activity of 2,3-Anhydr...
A series of 3-descladinosyl-2,3-anhydro-6-O-methylerythromycin A 11,12-carbamate analogues have been synthesized and evaluated for antibacterial activity. These compounds were... -
Metal−Metal Multiple Bonds in Early/Late Heterobimetallics Support Unusual Tr...
Reduction of Zr/Co heterobimetallic complexes ICo(MesNPiPr2)3ZrCl (1) and ICo(iPrNPiPr2)3ZrCl (2) with excess Na/Hg under N2, followed by subsequent benzene extraction to remove... -
r37980778c78--5cf7129e178d429abbc7becb7437076a
An efficient and practical process to generate β-C-arylglucoside derivatives was achieved. The process described involves Lewis acid mediated ionic reduction of a peracetylated... -
Efficient Synthesis of MUC4 Sialylglycopeptide through the New Sialylation Us...
Sialylation reactions using a new sialyl donor, diethyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-O-β-d-glycero-d-galacto-2-nonulopyranosylonamide phosphite... -
r37980778c78--171b2989a7b99d872f8aab415bba7cb6
A new and promising group of antibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged... -
r37980778c78--dc669ea7dab313dcdfbab5d71f789ca6
The polyfluorination of α-(arylthio)carbonyl compounds was achieved by a successive application of polyfluorination using IF5, Friedel−Crafts arylation, and desulfurizing... -
The Chemistry Development Kit in the Netherlands
Talk at the NBIC2012 meeting, see https://www.nbic.nl/about-nbic/nbic-conferences/nbic-conference-2012/programme/programme-april-25-detailed/index.html. -
Ventajas del formato ePub para la difusión de contenidos en Humanidades: just...
Una versión en pdf del contenido está disponible en https://doi.org/10.5281/zenodo.2580057
