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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,...
Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a... -
r37980778c78--56fcee8741a21a8729fa2db393bd30b0
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The... -
r37980778c78--fe4e83e064bdf00dc834ea490c40288c
A ratiometric fluorescent biosensor for Hg2+ is constructed from the MerR protein and a duplex DNA containing a pyrene excimer. -
Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (...
A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and... -
Inherently Chiral Biscalix[4]arenes: Design and Syntheses
Inherently chiral biscalix[4]arenes have been designed and synthesized by covalently assembling two calix[4]arene building blocks in a 1,3-position linking with 1,2-position... -
r37980778c78--566516baee56754d67c275c2225a172b
We previously prepared the oligonucleotides (ODNs) conjugated to an anthraquinone (AQ) group via one carbon linker at the 2′-sugar position. When these modified ODNs bind to... -
Ventajas del formato ePub para la difusión de contenidos en Humanidades: just...
Una versión en pdf del contenido está disponible en https://doi.org/10.5281/zenodo.2580057 -
A Ti<sub>2</sub>Ru<sub>2</sub>Pd<sub>2</sub> Oxo−Sulfido Cluster Synthesized ...
A Ti2Ru2Pd2 Oxo−Sulfido Cluster Synthesized by Linking Two Rationally Preorganized TiRuPdS2 Heterotrimetallic Units with an Oxo Ligand: Its Reaction with an Alkyne -
r37980778c78--8ed458fc46b46e50526a39ec3d4c93da
A new modification of 2−5A-antisense, 2−5A-iso-antisense, has been developed based on a reversal of the direction of the polarity of the antisense domain of a 2−5A-antisense... -
Damage potential of Drosophila suzukii and development of phytosanitary measu...
Slide of the Euphresco project 'Damage potential of Drosophila suzukii and development of phytosanitary measures' (DROSKII) Project funded through the Euphresco network -
Design of Organocatalysts for Asymmetric Direct Syn-Aldol Reactions
Two new organocatalysts 3a and 3b, derived from l-leucine and (S)-β-amino alcohols that were prepared from l-valine, were designed and afforded the direct syn-aldol reactions of... -
Sensitive and Convenient Yeast Reporter Assay for High-Throughput Analysis by...
The yeast reporter assay has been widely used in various applications such as detection of endocrine disruptors and analysis of protein−protein interactions by the yeast... -
r37980778c78--a5ea08454d67bc39d011c4600a0fc44f
The generation and synthetic application of stable carbanions situated in the β position from fluorine atom(s) are described. Palladium(0)-catalyzed allylation reactions under... -
Reactions of α,α‘-Dihydroxy Ketones with Phosgene. Structural Requirements fo...
α,α‘-Dihydroxy ketones having two OH groups that can come into close proximity react with phosgene in the presence of DMAP to produce 1,3-dioxane-2,5-diones. When covalent... -
r37980778c78--1b7126077cba5fa4d30974e237410b0b
Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT6 receptor ligands with improved... -
Controlling the Carbon Nanotube-to-Medium Conductivity Ratio for Dielectropho...
The surface conductivity of colloidal nanotubes, induced by ionic surfactants, is known to affect alternating current dielectrophoresis, which has been actively investigated... -
Activation of p300 Histone Acetyltransferase by Small Molecules Altering Enzy...
Reversible acetylation of nucleosomal histones and nonhistone proteins play pivotal roles in the regulation of all the DNA templated phenomenon. Dysfunction of the enzymes... -
r37980778c78--846564b65f52c385ecb3cccfd64a98dc
Protein ADP-ribosyltransferases catalyze the transfer of adenosine diphosphate ribose (ADP-ribose) from nicotinamide adenine dinucleotide (NAD) onto specific target proteins.... -
r37980778c78--ec64854d28963dbfea779d21e231f465
The rapid increase of obesity-associated diabetes has created urgent demands for more effective antidiabetic therapies and pharmaceuticals that are able to address the problems... -
An Icosahedral Array of Methyl Groups Supported by an Aromatic Borane Scaffol...
An Icosahedral Array of Methyl Groups Supported by an Aromatic Borane Scaffold: The [closo-B12(CH3)12]2- Ion
