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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,...
Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a... -
r37980778c78--56fcee8741a21a8729fa2db393bd30b0
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The... -
r37980778c78--fe4e83e064bdf00dc834ea490c40288c
A ratiometric fluorescent biosensor for Hg2+ is constructed from the MerR protein and a duplex DNA containing a pyrene excimer. -
r37980778c78--566516baee56754d67c275c2225a172b
We previously prepared the oligonucleotides (ODNs) conjugated to an anthraquinone (AQ) group via one carbon linker at the 2′-sugar position. When these modified ODNs bind to... -
Ventajas del formato ePub para la difusión de contenidos en Humanidades: just...
Una versión en pdf del contenido está disponible en https://doi.org/10.5281/zenodo.2580057 -
A Ti<sub>2</sub>Ru<sub>2</sub>Pd<sub>2</sub> Oxo−Sulfido Cluster Synthesized ...
A Ti2Ru2Pd2 Oxo−Sulfido Cluster Synthesized by Linking Two Rationally Preorganized TiRuPdS2 Heterotrimetallic Units with an Oxo Ligand: Its Reaction with an Alkyne -
Damage potential of Drosophila suzukii and development of phytosanitary measu...
Slide of the Euphresco project 'Damage potential of Drosophila suzukii and development of phytosanitary measures' (DROSKII) Project funded through the Euphresco network -
Design of Organocatalysts for Asymmetric Direct Syn-Aldol Reactions
Two new organocatalysts 3a and 3b, derived from l-leucine and (S)-β-amino alcohols that were prepared from l-valine, were designed and afforded the direct syn-aldol reactions of... -
Reactions of α,α‘-Dihydroxy Ketones with Phosgene. Structural Requirements fo...
α,α‘-Dihydroxy ketones having two OH groups that can come into close proximity react with phosgene in the presence of DMAP to produce 1,3-dioxane-2,5-diones. When covalent... -
r37980778c78--1b7126077cba5fa4d30974e237410b0b
Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT6 receptor ligands with improved... -
Controlling the Carbon Nanotube-to-Medium Conductivity Ratio for Dielectropho...
The surface conductivity of colloidal nanotubes, induced by ionic surfactants, is known to affect alternating current dielectrophoresis, which has been actively investigated... -
Activation of p300 Histone Acetyltransferase by Small Molecules Altering Enzy...
Reversible acetylation of nucleosomal histones and nonhistone proteins play pivotal roles in the regulation of all the DNA templated phenomenon. Dysfunction of the enzymes... -
r37980778c78--e88f8d488d533574ad314f400c833006
Benzheterazole derivatives with ethylene and phenyl linkers have been studied as model compounds to understand the role of (i) aromatic and heteroaromatic rings on the... -
Alternative Global Goodness Metrics and Sensitivity Analysis: Heuristics to ...
We introduce two ways of testing the robustness of conclusions from studies comparing virtual screening methods: alternative “global goodness” metrics and sensitivity analysis.... -
A Rational Approach to Minimal High-Resolution Cross-Reactive Arrays
We report a rational approach to the construction of cross-reactive arrays for steroids consisting of five to seven sensors incorporating modified oligonucleotides. The sensors... -
r37980778c78--d1bfb7661c219b26839ddb91e0e85b6b
l-Glycals can be prepared in seven steps from readily available d-glucals, enabling the facile construction of mirror-image carbohydrates such as the l-lactosamine derivative... -
Exclusive C−C Activation in the Rhodium(I) PCN Pincer Complex. A Computationa...
The mechanism of competitive intramolecular C−C and C−H bond activation in PCN pincer complexes of rhodium(I) has been studied computationally. Experimentally this system... -
r37980778c78--2fa81ba51032333075d4680840131d78
The photochemistry of stilbene is investigated using ab initio quantum chemistry with complete active space self-consistent field (CASSCF) and multireference perturbation theory... -
Reduced Excimer Formation in Polyfluorenes by Introducing Coil-like Poly[pent...
Conjugated polymers are of special interest due to their excellent optical and optoelectrical properties both in the solid state and in selective solvents. They have... -
Air-Stable Trialkylphosphonium Salts: Simple, Practical, and Versatile Repla...
Trialkylphosphines furnish unusual, sometimes unique, reactivity in a range of transformations. Unfortunately, their utility is compromised by their sensitivity to oxidation. We...
