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Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Periostin involved in the activated hepatic stellate cells-induced progressio...
Abstract Background Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs)... -
ERα-36 regulates progesterone receptor activity in breast cancer
Abstract Background Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR),... -
Tonic ATP-mediated growth suppression in peripheral nerve glia requires arres...
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity... -
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrat...
Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by... -
A Waste Supply-Use Analysis of Australian Waste Flows
Abstract In this paper we apply the Lenzen and Reynolds (2014) Waste Supply Use Table extension of Nakamura and Kondo’s (2002a) Waste Input–Output (WIO) framework to the 2008... -
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
Abstract Background Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.... -
TBCRC 002: a phase II, randomized, open-label trial of preoperative letrozole...
Abstract Background In preclinical studies, the expression of vascular endothelial growth factor (VEGF) in hormone receptor-positive breast cancer is associated with... -
Training emergency physicians in sex- and gender-based medicine: assessing at...
Abstract Background Sex and gender influence disease presentation, treatment, healthcare access, and long-term outcomes. It is uncertain to what extent sex- and gender-based... -
TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigen...
Abstract Background Although ductal carcinoma in situ (DCIS) is a non-invasive breast cancer, many DCIS lesions may progress to invasive cancer and the genes and pathways... -
Isolation and functional validation of the CmLOX08 promoter associated with s...
Abstract Background Lipoxygenases (LOXs) play significant roles in abiotic stress responses, and identification of LOX gene promoter function can make an important contribution... -
PYK2 promotes HER2-positive breast cancer invasion
Abstract Background Metformin, a biguanide, is one of the most commonly prescribed treatments for type 2 diabetes and has recently been recommended as a potential drug candidate... -
Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch...
Abstract Background Secretory recombinant protein production with Pichia (syn. Komagataella) pastoris is commonly associated with the induction of an unfolded protein response... -
A principal components method constrained by elementary flux modes: analysis ...
Abstract Background Non-negative linear combinations of elementary flux modes (EMs) describe all feasible reaction flux distributions for a given metabolic network under the... -
Prolactin blocks the expression of receptor activator of nuclear factor κB li...
Abstract Background Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we... -
Inverse association between estrogen receptor-α DNA methylation and breast co...
Abstract Background Estrogen receptor-α (ER-α) is a transcriptional regulator, which mediates estrogen-dependent breast development, as well as breast tumorigenesis. The... -
Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of...
Abstract Background Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and... -
The cotton GhWIN2 gene activates the cuticle biosynthesis pathway and influen...
Abstract Background Metabolic pathways are interconnected and yet relatively independent. Genes involved in metabolic modules are required for the modules to run. Study of the... -
Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation...
Abstract Background Estrogen promotes breast cancer development and progression mainly through estrogen receptor (ER). However, blockage of estrogen production or action... -
Regulation of platelet-activating factor-mediated interleukin-6 promoter acti...
Abstract Background An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of...
