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Bioavailability of subcutaneous and intramuscular administrated buprenorphine...
Abstract Background Buprenorphine is one of the most used analgesics for postoperative pain in rabbits. The recommended dose in rabbits (0.01–0.05 mg/kg) is the same for... -
Removal of the product from the culture medium strongly enhances free fatty a...
Abstract Background Cyanobacterial mutants engineered for production of free fatty acids (FFAs) secrete the products to the medium and hence are thought to be useful for biofuel... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Differential expression of E-type prostanoid receptors 2 and 4 in microglia s...
Abstract Background Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic... -
Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) pr...
Abstract Background Larvae of Echinococcus granulosus (sensu lato) dwell in host organs for a long time but elicit only a mild inflammatory response, which indicates that the... -
cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GP...
Abstract Background The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα,... -
Efficacy of andrographolide in not active progressive multiple sclerosis: a p...
Abstract Background Multiple sclerosis (MS) is a chronic immune mediated disease and the progressive phase appears to have significant neurodegenerative mechanisms. The... -
Highly active promoters and native secretion signals for protein production d...
Abstract Background The filamentous ascomycete Aspergillus niger is used in many industrial processes for the production of enzymes and organic acids by batch and fed-batch... -
Design, synthesis and biological activity of hydroxybenzoic acid ester conjug...
Abstract We prepared 16 novel hydroxybenzoic acid ester conjugates of phenazine-1-carboxylic acid (PCA) and investigated their biological activity. Most of the synthesized... -
Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: method de...
Abstract Objective Norepinephrine (NE), a sympathetic neurotransmitter, is often measured in plasma as an index of sympathetic activity. To better understand NE dynamics, it is... -
Synthesis and biological activity of myricetin derivatives containing 1,3,4-t...
Abstract Background Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin... -
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mic...
Abstract Background Nonalcoholic fatty liver disease is one of the most common liver diseases in the world and is a typical hepatic manifestation of metabolic syndrome which is... -
Non-pungent long chain capsaicin-analogs arvanil and olvanil display better a...
The nutritional compound capsaicin inhibits the invasion of many types of human cancers. The clinical development of capsaicin as an anti-cancer drug is limited due to its... -
Pancreatic cancer-initiating cell exosome message transfer into noncancer-ini...
Abstract Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed,... -
Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa ...
Abstract Background Oxidative stress and renal apoptosis play a significant role in the progression of diabetic nephropathy. The tubers of Pueraria tuberosa (Roxb. ex Willd.)... -
Effects of prolonged direct hemoperfusion using a polymyxin B immobilized fib...
Abstract Background The aim of this study was to evaluate the effect of prolonged direct hemoperfusion using polymyxin B immobilized fiber cartridges (PMX-DHP) on interleukin-6... -
A toolset of constitutive promoters for metabolic engineering of Rhodosporidi...
Abstract Background Rhodosporidium toruloides is a promising host for the production of bioproducts from lignocellulosic biomass. A key prerequisite for efficient pathway... -
Potential in vitro anti-allergic, anti-inflammatory and cytotoxic activities ...
Abstract Background The root of Baliospermum montanum has been used as an ingredient of traditional Thai medicines for the treatments of several diseases including itching... -
Comparative efficacy analysis of anti-microbial peptides, LL-37 and indolicid...
Abstract Background Antimicrobial peptides (AMPs) have the potential to serve as an alternative to antibiotic. AMPs usually exert bactericidal activity via direct killing of... -
Untargeted metabolomics reveals the effect of lovastatin on steroid-induced n...
Abstract Purpose Lovastatin is an important medicine and it shows a significant effect against glucocorticoid-induced necrosis of the femoral head. This study aimed to...
